Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 7/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 7/20 | 0.50 |
| ▸ | RELA | Q04206 | 7/20 | 0.50 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.50 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | KCNA3 | P22001 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23728437 | 0.83 | NFKB1 (0.47) | NFKB1NFKB2RELASLC5A1SLC5A2 | |
| SCHEMBL23728227 | 0.83 | NFKB1 (0.47) | NFKB1NFKB2RELASLC5A1SLC5A2 | |
| SCHEMBL25437405 | 0.77 | NFKB1 (0.52) | NFKB1NFKB2RELASLC5A1SLC5A2 | |
| SCHEMBL12599531 | 0.76 | HPGD (0.42) | NFKB1NFKB2RELAKMT2AMEN1 | |
| SCHEMBL25301405 | 0.75 | NFKB1 (0.50) | NFKB1NFKB2RELASLC5A1SLC5A2 | |
| SCHEMBL17150170 | 0.74 | NFKB1 (0.66) | NFKB1NFKB2RELACYP2C9CYP2C19 | |
| SCHEMBL12599524 | 0.74 | MAPT (0.58) | NFKB1NFKB2RELASLC5A1SLC5A2 | |
| SCHEMBL15620334 | 0.74 | NFKB1 (0.48) | NFKB1NFKB2RELACYP19A1CYP2C9 | |
| SCHEMBL30335008 | 0.74 | MAPT (0.58) | NFKB1NFKB2RELASLC5A1SLC5A2 | |
| SCHEMBL25301601 | 0.73 | MAPT (0.52) | NFKB1NFKB2RELAMAOBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8586768-B2 | Design, synthesis and functional characterization of rottlerin analogs | IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 2013-11-19 | — | — | US | disclosed |
| US-20110112182-A1 | DESIGN, SYNTHESIS AND FUNCTIONAL CHARACTERIZATION OF ROTTLERIN ANALOGS | IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 2011-05-12 | — | — | US | disclosed |
| US-20110112182-A1 | DESIGN, SYNTHESIS AND FUNCTIONAL CHARACTERIZATION OF ROTTLERIN ANALOGS | IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 2011-05-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110112182-A1 | DESIGN, SYNTHESIS AND FUNCTIONAL CHARACTERIZATION OF ROTTLERIN ANALOGS | PRKCH, PRKCB, PRKCA | NFKB1 1069/4885NFKB2 1366/4885RELA 2357/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.