Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | BRD1 | O95696 | 1/20 | 0.41 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.41 |
| ▸ | BRPF3 | Q9ULD4 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
| ▸ | METAP2 | P50579 | 1/20 | 0.38 |
| ▸ | EDNRB | P24530 | 2/20 | 0.38 |
| ▸ | EDNRA | P25101 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1542958 | 0.80 | ALDH1A1 (0.53) | IDH1SIGMAR1MAPTKMT2AMEN1 | |
| SCHEMBL24435816 | 0.79 | BRD4 (0.45) | IDH1BRD4MAPTKMT2AMEN1 | |
| SCHEMBL15001572 | 0.79 | SLC22A12 (0.42) | CA1CA2KMT2AMEN1SLC22A12 | |
| SCHEMBL31046908 | 0.78 | METAP2 (0.60) | MAPTKMT2AMEN1ALDH1A1METAP2 | |
| SCHEMBL23141230 | 0.78 | METAP2 (0.60) | MAPTKMT2AMEN1ALDH1A1METAP2 | |
| SCHEMBL27183080 | 0.77 | THRB (0.42) | IDH1SIGMAR1MAPTKMT2AMEN1 | |
| SCHEMBL12649965 | 0.76 | CA1 (0.43) | IDH1CA1CA2SIGMAR1MAPT | |
| SCHEMBL23141236 | 0.74 | METAP2 (0.47) | ALDH1A1METAP2 | |
| SCHEMBL12932924 | 0.74 | ALDH1A1 (0.50) | CA2ALDH1A1THRBNPC1RAB9A | |
| SCHEMBL14864698 | 0.72 | SIGMAR1 (0.45) | SIGMAR1MAPTKMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943639-B2 | Such as 6-benzenesulfonyl-4-piperazin-1-yl-quinoline hydrochloride; for treatment of central nervous system and/or 5- HT6 receptor related disorders; for weight gain/loss | PROXIMAGEN LIMITED (GB) | 2011-05-17 | — | — | US | disclosed |