Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 16/20 | 0.59 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.50 |
| ▸ | RORC | P51449 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12652521 | 0.94 | TRPA1 (0.61) | TRPA1TRPV4 | |
| SCHEMBL1799679 | 0.80 | TRPA1 (0.61) | TRPA1TRPV4RORC | |
| SCHEMBL14479301 | 0.77 | TRPA1 (0.74) | TRPA1TRPV4 | |
| SCHEMBL14479300 | 0.76 | TRPA1 (0.75) | TRPA1TRPV4 | |
| SCHEMBL1799914 | 0.76 | TRPA1 (0.63) | TRPA1TRPV4 | |
| SCHEMBL12618156 | 0.75 | TRPA1 (0.84) | TRPA1TRPV4 | |
| SCHEMBL13671691 | 0.74 | TRPA1 (1.00) | TRPA1TRPV4RORC | |
| SCHEMBL13175031 | 0.73 | TRPA1 (0.59) | TRPA1TRPV4RORC | |
| SCHEMBL1802172 | 0.73 | PLA2G2A (0.46) | — | |
| SCHEMBL13075853 | 0.73 | TRPA1 (0.54) | TRPA1TRPV4RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7951814-B2 | Quinazolinedione derivatives as TRPA1 modulators | GLENMARK PHARMACEUTICALS, S.A. (CH) | 2011-05-31 | — | — | US | disclosed |
| WO-2010004390-A1 | QUINAZOLINE DIONE DERIVATIVES AS TRPA1 MODULATORS | GLENMARK PHARMACEUTICALS, S.A. (CH) | 2010-01-14 | — | — | WO | disclosed |
| US-20090325987-A1 | QUINAZOLINEDIONE DERIVATIVES AS TRPA1 MODULATORS | GLENMARK PHARMACEUTICALS, S.A. (CH) | 2009-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090325987-A1 | QUINAZOLINEDIONE DERIVATIVES AS TRPA1 MODULATORS | TRPA1, TRPV1, TRPC3 | TRPA1 1/4885TRPV4 6/4885RORC 557/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.