Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.42 |
| ▸ | PLA2G2A | P14555 | 8/20 | 0.40 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2005137 | 0.84 | PTGS2 (0.48) | PTGS2PLA2G2APLA2G1B | |
| SCHEMBL12628278 | 0.81 | PTGS2 (0.43) | PTGS2PLA2G2APLA2G1B | |
| SCHEMBL12628604 | 0.77 | PLA2G2A (0.34) | PTGS2PLA2G2A | |
| SCHEMBL2008798 | 0.77 | PTGS2 (0.60) | PTGS2PLA2G2APLA2G1B | |
| SCHEMBL12628454 | 0.77 | CNR1 (0.42) | PTGS2PLA2G2A | |
| SCHEMBL12570774 | 0.76 | CES1 (0.47) | PTGS2PLA2G2A | |
| SCHEMBL2002519 | 0.75 | FAAH (0.41) | PTGS2PLA2G2A | |
| SCHEMBL2006756 | 0.74 | PTGS2 (0.51) | PTGS2PLA2G2APLA2G1B | |
| SCHEMBL12628455 | 0.70 | MAPT (0.34) | PTGS2PLA2G2A | |
| SCHEMBL12628458 | 0.69 | HCRTR2 (0.38) | PTGS2PLA2G2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |
| US-20090264653-A1 | USEFUL INDOLE COMPOUNDS | IRONWOOD PHARMACEUTICALS, INC. | 2009-10-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090264653-A1 | USEFUL INDOLE COMPOUNDS | FAAH, FAAH2, AANAT | PTGS2 460/4885PLA2G2A 326/4885PLA2G1B 220/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.