Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | SNCA | P37840 | 2/20 | 0.45 |
| ▸ | CASP6 | P55212 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | TTR | P02766 | 1/20 | 0.40 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | THRA | P10827 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL515466 | 0.89 | MAPT (0.54) | MAPTALDH1A1SNCACASP6TSHR | |
| SCHEMBL27986576 | 0.84 | HTR1A (0.50) | MAPTALDH1A1SNCACASP6TSHR | |
| SCHEMBL1874991 | 0.78 | ALDH1A1 (0.50) | MAPTALDH1A1SNCACASP6TSHR | |
| SCHEMBL28818830 | 0.78 | CYP3A4 (0.44) | MAPTALDH1A1SNCATSHRCYP3A4 | |
| SCHEMBL27918314 | 0.78 | ALDH1A1 (0.50) | MAPTALDH1A1TSHRCYP3A4SMN1; SMN2 | |
| Methoxymethane SCHEMBL27521593 | 0.78 | HTR1A (0.46) | MAPTALDH1A1CASP6TSHRCYP3A4 | |
| SCHEMBL10608137 | 0.78 | TSHR (0.58) | MAPTALDH1A1SNCACASP6TSHR | |
| SCHEMBL17154335 | 0.77 | POLB (0.63) | MAPTALDH1A1TSHRPOLBSMN1; SMN2 | |
| SCHEMBL2135817 | 0.77 | ALDH1A1 (0.45) | MAPTALDH1A1SNCATSHRCYP3A4 | |
| SCHEMBL30477507 | 0.76 | SNCA (0.62) | MAPTALDH1A1SNCATSHRPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7939528-B2 | Heterocycle compounds | GLAXOSMITHKLINE LLC (US) | 2011-05-10 | — | — | US | disclosed |
| US-20090054431-A1 | NOVEL HETEROCYCLE COMPOUNDS | GLAXOSMITHKLINE LLC | 2009-02-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054431-A1 | NOVEL HETEROCYCLE COMPOUNDS | OPRK1, OPRL1, OPRD1 | MAPT 4563/4885ALDH1A1 1161/4885SNCA 1533/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.