Sugi Predict

Sugi Predict / Compounds / SCHEMBL1263646

SCHEMBL1263646

SCHEMBL1263646

C=CCc1ccc(O)c(-n2nc3ccccc3n2)c1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NPC1 O15118 3/20 0.55
▸ RAB9A P51151 3/20 0.55
▸ LMNA P02545 1/20 0.55
▸ XDH P47989 1/20 0.51
▸ GABRA1 P14867 7/20 0.50
▸ GABRB2 P47870 7/20 0.50
▸ ALDH1A1 P00352 3/20 0.50
▸ MEN1 O00255 3/20 0.50
▸ CNR2 P34972 3/20 0.50
▸ KMT2A Q03164 3/20 0.50
▸ GAA P10253 2/20 0.50
▸ MAPT P10636 2/20 0.50
▸ CNR1 P21554 2/20 0.50
▸ KDM4E B2RXH2 2/20 0.50
▸ HPGD P15428 2/20 0.50
▸ ALDH2 P05091 1/20 0.50
▸ AKR1B1 P15121 1/20 0.50
▸ PPARG P37231 1/20 0.50
▸ PPARD Q03181 1/20 0.50
▸ NPSR1 Q6W5P4 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18927910 0.87 NPC1 (0.56) NPC1RAB9ALMNAXDHGABRA1
SCHEMBL2731448 0.86 XDH (0.45) NPC1RAB9ALMNAXDHGABRA1
SCHEMBL7705012 0.86 TNKS (0.59) NPC1RAB9ALMNAXDHGABRA1
SCHEMBL11668225 0.85 XDH (0.45) NPC1RAB9ALMNAXDHGABRA1
SCHEMBL502192 0.83 NPC1 (0.59) NPC1RAB9ALMNAALDH1A1MEN1
SCHEMBL11892463 0.83 RAB9A (0.63) NPC1RAB9ALMNAALDH1A1MEN1
SCHEMBL5241062 0.82 NPC1 (0.46) NPC1RAB9ALMNAXDHGABRA1
SCHEMBL30240912 0.81 NPC1 (0.61) NPC1RAB9ALMNAALDH1A1MEN1
SCHEMBL76414 0.81 NPC1 (0.61) NPC1RAB9ALMNAALDH1A1MEN1
SCHEMBL7698243 0.81 TNKS (0.46) NPC1RAB9ALMNAXDHGABRA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-7247392-A — — None — — JP disclosed
JP-6321918-A — — None — — JP disclosed
JP-4187679-A — — None — — JP disclosed
JP-11279161-A — — None — — JP disclosed
EP-3383854-B1 WATER-SOLUBLE UV-ABSORBING COMPOUNDS AND USES THEREOF ALCON INC (CH) 2021-03-03 — — EP disclosed
US-10823983-B2 UV-absorbing vinylic monomers and uses thereof ALCON INC. (CH) 2020-11-03 — — US disclosed
US-10472319-B2 Water-soluble UV-absorbing compounds and uses thereof NOVARTIS AG (CH) 2019-11-12 — — US disclosed
US-20190256455-A1 WATER-SOLUBLE UV-ABSORBING COMPOUNDS AND USES THEREOF ALCON INC. (CH) 2019-08-22 — — US disclosed
US-10322993-B2 Water-soluble UV-absorbing compounds and uses thereof NOVARTIS AG (CH) 2019-06-18 — — US disclosed
US-10254567-B2 UV-absorbing vinylic monomers and uses thereof NOVARTIS AG (CH) 2019-04-09 — — US disclosed
US-5240975-A Photostability CIBA-GEIGY CORPORATION (US) 1993-08-31 — — US disclosed
JP-H04187679-A PREPARATION OF 2-(2-HYDROXYPHENYL)BENZOTRIAZOLE DERIVATIVE SHIPURO KASEI KK 1992-07-06 — — JP disclosed
US-5095062-A Photostability CIBA-GEIGY CORPORATION (US) 1992-03-10 — — US disclosed
US-4973701-A LIGHT STABILIZERS FOR PHOTOGRAPHY AND POLYMERS CIBA-GEIGY CORPORATION (US) 1990-11-27 — — US disclosed
EP-0337942-A1 Liquid substituted 2H-benzotriazole mixtures CIBA-GEIGY AG (CH) 1989-10-18 — — EP disclosed
US-4652656-A UV-absorbing monomer and polymers thereof ROHM GMBH (DE) 1987-03-24 — — US disclosed
US-4612358-A 2-/2*HYDROXY-3*-METHACRYLAMIDOMETHYL-5-ALKYLPHENYL)-BENZOTRIAZOLE ROHM GMBH (DE) 1986-09-16 — — US disclosed
US-4321396-A Copolymerizable, ultraviolet light absorber allyloxy-2-(2H-benzotriazol-2-yl)-4-alkylbenzenes GAF CORPORATION (US) 1982-03-23 — — US disclosed
US-4260768-A Copolymerizable, ultraviolet light absorber 2-(2H-benzotriazol-2-yl)-4-alkylphenol acrylic acid esters GAF CORPORATION (US) 1981-04-07 — — US disclosed
US-4104432-A ACRYLIC POLYMER, POLYISOCYANATE AND UNSATURATED POLYESTER TOYODA GOSEI KABUSHIKI-KAISHA (TOYODA SYNTHETICS CO., LTD.) (JP) 1978-08-01 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10823983-B2 UV-absorbing vinylic monomers and uses thereof UACA, VCL, CRYZ NPC1 4585/4885RAB9A 1944/4885LMNA 924/4885
US-10254567-B2 UV-absorbing vinylic monomers and uses thereof UACA, VCL, CRYZ NPC1 4585/4885RAB9A 1944/4885LMNA 924/4885
US-10472319-B2 Water-soluble UV-absorbing compounds and uses thereof CRYZ, UACA, XRCC5 NPC1 4295/4885RAB9A 1365/4885LMNA 137/4885
US-10322993-B2 Water-soluble UV-absorbing compounds and uses thereof CRYZ, UACA, XRCC5 NPC1 4295/4885RAB9A 1365/4885LMNA 137/4885
US-20190256455-A1 WATER-SOLUBLE UV-ABSORBING COMPOUNDS AND USES THEREOF CRYZ, UACA, XRCC5 NPC1 4295/4885RAB9A 1365/4885LMNA 137/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.