Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | PGK1 | P00558 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | GSK3B | P49841 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.39 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.39 |
| ▸ | CLK2 | P49760 | 1/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.39 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.39 |
| ▸ | PLK1 | P53350 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12876460 | 0.83 | LMNA (0.47) | L3MBTL1PGK1KMT2AGSK3BCYP2C9 | |
| SCHEMBL12639113 | 0.80 | L3MBTL1 (0.52) | L3MBTL1PGK1KMT2AGSK3BCYP2C9 | |
| SCHEMBL22190995 | 0.79 | KMT2A (0.41) | L3MBTL1KMT2AGSK3BCYP2C9PRKCQ | |
| SCHEMBL1804900 | 0.79 | PIN1 (0.57) | L3MBTL1PGK1PRKCQSTK17AMAPT | |
| SCHEMBL11749924 | 0.76 | TDP1 (0.55) | PGK1KMT2ACYP2C9CYP3A4CYP2D6 | |
| SCHEMBL1521438 | 0.75 | GAA (0.46) | L3MBTL1PGK1KMT2ACYP2D6SMN1; SMN2 | |
| SCHEMBL28496190 | 0.75 | PGK1 (0.50) | L3MBTL1PGK1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL12639147 | 0.74 | KMT2A (0.43) | KMT2ASMN1; SMN2ALDH1A1MEN1MAPT | |
| SCHEMBL1521840 | 0.74 | ALDH1A1 (0.40) | KMT2ACYP3A4CYP2D6SMN1; SMN2ALDH1A1 | |
| SCHEMBL13517647 | 0.73 | ALDH1A1 (0.52) | KMT2ASMN1; SMN2ALDH1A1MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7947695-B2 | Inhibitors of cell cycle kinases such as cyclin dependent kinase CDK4 and/or the Aurora kinases; use in combination with an anticancer agent | JANSSEN PHARMACEUTICA NV (BE) | 2011-05-24 | — | — | US | disclosed |
| US-20080070914-A1 | Inhibitors of cell cycle kinases such as cyclin dependent kinase CDK4 and/or the Aurora kinases; use in combination with an anticancer agent | JANSSEN-CILAG (FR) | 2008-03-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080070914-A1 | Inhibitors of cell cycle kinases such as cyclin dependent kinase CDK4 and/or the Aurora kinases; use in combination with an anticancer agent | CDK1, CDK2, CDK4 | L3MBTL1 2650/4885PGK1 302/4885KMT2A 490/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.