Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G7 | Q13093 | 5/20 | 0.34 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.33 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.33 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.33 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.33 |
| ▸ | PTP4A3 | O75365 | 1/20 | 0.33 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.31 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.31 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12668433 | 0.74 | ABCC9 (0.32) | ABCC9ABCC8KCNJ11KCNJ8PTP4A3 | |
| SCHEMBL28777283 | 0.71 | ABCC9 (0.37) | PLA2G7ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL29725673 | 0.71 | ABCC9 (0.37) | PLA2G7ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL31734535 | 0.71 | PTP4A3 (0.38) | PLA2G7ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL14498539 | 0.68 | ABCC9 (0.39) | PLA2G7ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL25004524 | 0.67 | SLC6A4 (0.38) | PLA2G7ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL3712044 | 0.67 | CYP11B1 (0.51) | PLA2G7ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL2082363 | 0.67 | PGR (0.36) | PLA2G7ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL5109838 | 0.63 | QDPR (0.50) | PLA2G7 | |
| SCHEMBL31420544 | 0.62 | PGR (0.34) | ABCC9ABCC8KCNJ11KCNJ8PTP4A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012158550-A2 | SELECTIVE HETEROCYCLIC SPHINGOSINE 1 PHOSPHATE RECEPTOR MODULATORS | RECEPTOS, INC. (US) | 2012-11-22 | — | — | WO | disclosed |
| WO-2011060391-A1 | SELECTIVE HETEROCYCLIC SPHINGOSINE 1 PHOSPHATE RECEPTOR MODULATORS | RECEPTOS, INC. (US) | 2011-05-19 | — | — | WO | disclosed |