Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12667303 | 0.81 | ALDH1A1 (0.46) | SMN1; SMN2KDM4EKMT2ANPSR1MAPK1 | |
| SCHEMBL12669700 | 0.74 | ATM (0.40) | SMN1; SMN2KDM4EKMT2AMAPTGAA | |
| SCHEMBL12668966 | 0.69 | ALDH1A1 (0.36) | KDM4EKMT2AALDH1A1TSHRPOLB | |
| SCHEMBL12502321 | 0.68 | AR (0.54) | SMN1; SMN2KDM4EKMT2AMAPTTHRB | |
| SCHEMBL1890367 | 0.67 | GAA (0.48) | SMN1; SMN2KDM4EKMT2AMAPTTHRB | |
| SCHEMBL29264866 | 0.67 | SLC6A3 (0.51) | SMN1; SMN2KDM4EKMT2AMAPTTHRB | |
| SCHEMBL29264847 | 0.67 | KDM4E (0.50) | SMN1; SMN2KDM4EKMT2AMAPTGAA | |
| SCHEMBL29264868 | 0.67 | MAPK8 (0.50) | SMN1; SMN2KDM4EKMT2AMAPTNPSR1 | |
| SCHEMBL13120820 | 0.66 | MAPK8 (0.49) | SMN1; SMN2KDM4EKMT2AMAPTNPSR1 | |
| SCHEMBL23452060 | 0.66 | KDM4E (0.49) | SMN1; SMN2KDM4EKMT2AMAPTTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011060036-A1 | BICYCLIC COMPOUNDS AND METHODS OF USE THEREOF | SCHERING CORPORATION (US) | 2011-05-19 | — | — | WO | disclosed |