Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.45 |
| ▸ | WNT3A | P56704 | 1/20 | 0.45 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.45 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1267175 | 0.87 | ALDH1A1 (0.44) | NPC1RAB9ACTNNB1WNT3AALDH1A1 | |
| SCHEMBL1266359 | 0.85 | ALDH1A1 (0.50) | NPC1RAB9ACTNNB1WNT3AALDH1A1 | |
| SCHEMBL1265985 | 0.82 | GRIN2C (0.45) | NPC1RAB9AALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL1266774 | 0.80 | HTT (0.46) | ALDH1A1KDM4ELMNATSHRL3MBTL1 | |
| SCHEMBL1267179 | 0.79 | ALDH1A1 (0.46) | NPC1RAB9AALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL1267045 | 0.79 | KIF11 (0.48) | NPC1RAB9ASCD5ALDH1A1KDM4E | |
| SCHEMBL1267145 | 0.78 | ALDH1A1 (0.43) | NPC1RAB9ACTNNB1WNT3AALDH1A1 | |
| SCHEMBL1266012 | 0.77 | ADRA2C (0.55) | NPC1RAB9AALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL1267022 | 0.77 | NPC1 (0.47) | NPC1RAB9AALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL1266157 | 0.76 | TP53 (0.45) | NPC1ALDH1A1KDM4ESMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7879858-B2 | monoamine reuptake inhibitors such as (3-fluorophenyl)(1-(2-methoxyphenyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)methanone, used as antidepressants, anxiolytic agents and analgesics | GRUENENTHAL GMBH (DE) | 2011-02-01 | — | — | US | claimed |
| US-20090258880-A1 | Substituted Tetrahydropyrrolopyrazine Compounds and the Use Thereof in Pharmaceutical Compositions | GRUENENTHAL GMBH (DE) | 2009-10-15 | — | — | US | claimed |
| US-7879858-B2 | monoamine reuptake inhibitors such as (3-fluorophenyl)(1-(2-methoxyphenyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)methanone, used as antidepressants, anxiolytic agents and analgesics | GRUENENTHAL GMBH (DE) | 2011-02-01 | — | — | US | disclosed |
| US-20090258880-A1 | Substituted Tetrahydropyrrolopyrazine Compounds and the Use Thereof in Pharmaceutical Compositions | GRUENENTHAL GMBH (DE) | 2009-10-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090258880-A1 | Substituted Tetrahydropyrrolopyrazine Compounds and the Use Thereof in Pharmaceutical Compositions | DHPS, APC, CYP3A5 | NPC1 2158/4885RAB9A 3023/4885CTNNB1 1539/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.