SCHEMBL12670976

SCHEMBL12670976

C[Si](C)(C)CCOCn1cc2ccc(C(=O)O)cc2n1

nearest known ligand 0.40

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
HCAR3 P49019 6/20 0.40
NPC1 O15118 3/20 0.39
RAB9A P51151 2/20 0.39
MEN1 O00255 1/20 0.39
KMT2A Q03164 1/20 0.39
TDP1 Q9NUW8 1/20 0.38
KDM4C Q9H3R0 1/20 0.37
KDM4E B2RXH2 2/20 0.36
ALDH1A1 P00352 2/20 0.36
GAA P10253 1/20 0.36
MAPT P10636 1/20 0.36
HPGD P15428 1/20 0.36
PTGER4 P35408 2/20 0.36
KLKB1 P03952 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
THRB P10828 1/20 0.35
HSD17B10 Q99714 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15778085 0.90 NPC1 (0.39) NPC1MEN1KMT2AKDM4EALDH1A1
SCHEMBL29915403 0.89 NPC1 (0.50) NPC1KMT2AKDM4EPTGER4THRB
SCHEMBL1418432 0.88 KDM4E (0.42) NPC1RAB9AMEN1KMT2AKDM4E
SCHEMBL1417918 0.86 THRB (0.43) NPC1MEN1KMT2AKDM4EALDH1A1
SCHEMBL15778043 0.82 MAPT (0.41) NPC1RAB9AMEN1KMT2AALDH1A1
SCHEMBL15785617 0.82 MAPT (0.41) NPC1RAB9AMEN1KMT2AALDH1A1
SCHEMBL15778045 0.81 NPC1 (0.34) NPC1KLKB1THRB
SCHEMBL3376854 0.81 KDM4E (0.48) NPC1RAB9AMEN1KMT2AKDM4E
SCHEMBL2317816 0.81 DGAT1 (0.42) NPC1PTGER4KLKB1
SCHEMBL15785656 0.80 KDM4C (0.54) KDM4C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4053108-B1 COMPOUND CONTAINING BENZENE RING AND APPLICATION THEREOF WUHAN LL SCIENCE & TECHNOLOGY DEVELOPMENT CO LTD (CN) 2026-03-11 EP disclosed
US-20260055063-A1 COMPOUND CONTAINING BENZENE RING AND APPLICATION THEREOF WUHAN LL SCIENCE & TECHNOLOGY DEVELOPMENT CO LTD (CN) 2026-02-26 US disclosed
US-12503444-B2 Compound containing benzene ring and application thereof WUHAN LL SCIENCE AND TECHNOLOGY DEVELOPMENT CO., LTD. (CN) 2025-12-23 US disclosed
CN-114845996-B Benzene ring-containing compound and application thereof 武汉朗来科技发展有限公司 2023-09-12 CN disclosed
US-20230183182-A1 COMPOUND CONTAINING BENZENE RING AND APPLICATION THEREOF WUHAN LL SCIENCE AND TECHNOLOGY DEVELOPMENT CO., LTD. (CN) 2023-06-15 US disclosed
EP-4053108-A1 COMPOUND CONTAINING BENZENE RING AND APPLICATION THEREOF Wuhan LL Science and Technology Development Co., Ltd. (CN) 2022-09-07 EP disclosed
US-8377923-B2 Triazole derivative or salt thereof ASTELLAS PHARMA INC. (JP) 2013-02-19 US disclosed
US-20110105460-A1 TRIAZOLE DERIVATIVE OR SALT THEREOF ASTELLAS PHARMA INC. (JP) 2011-05-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260055063-A1 COMPOUND CONTAINING BENZENE RING AND APPLICATION THEREOF CNR2, RYR2, CNR1 HCAR3 173/4885NPC1 706/4885RAB9A 2296/4885
US-20110105460-A1 TRIAZOLE DERIVATIVE OR SALT THEREOF HSD11B1, HSD11B2, HSD3B1 HCAR3 765/4885NPC1 708/4885RAB9A 3358/4885
US-12503444-B2 Compound containing benzene ring and application thereof P2RX4, P2RX7, P2RX2 HCAR3 1253/4885NPC1 1217/4885RAB9A 3771/4885
US-20230183182-A1 COMPOUND CONTAINING BENZENE RING AND APPLICATION THEREOF P2RX4, P2RX7, P2RX2 HCAR3 1253/4885NPC1 1217/4885RAB9A 3771/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.