Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 2/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | DPP4 | P27487 | 2/20 | 0.40 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.38 |
| ▸ | TACR1 | P25103 | 1/20 | 0.38 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.36 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.36 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | THPO | P40225 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1157274 | 0.81 | PNMT (0.45) | SLC6A4SLC6A2SLC6A3DPP4LOXL2 | |
| SCHEMBL3282252 | 0.81 | NOS1 (0.43) | SLC6A4SLC6A2SLC6A3DPP4LOXL2 | |
| SCHEMBL1156843 | 0.81 | DPP4 (0.47) | SLC6A4SLC6A2SLC6A3DPP4LOXL2 | |
| SCHEMBL1157043 | 0.79 | SLC6A4 (0.60) | SLC6A4SLC6A2SLC6A3DPP4GRIN2D | |
| Hydrochloric Acid SCHEMBL9322527 | 0.78 | SLC6A4 (0.58) | SLC6A4SLC6A2SLC6A3DPP4GRIN2D | |
| Hydrochloric Acid SCHEMBL9322405 | 0.78 | SLC6A4 (0.58) | SLC6A4SLC6A2SLC6A3DPP4GRIN2D | |
| SCHEMBL9306936 | 0.77 | DPP4 (0.55) | SLC6A4SLC6A2SLC6A3DPP4LOXL2 | |
| SCHEMBL11664457 | 0.73 | TACR1 (0.41) | SLC6A4SLC6A2SLC6A3TACR1CYP1A2 | |
| SCHEMBL20844633 | 0.72 | TACR1 (0.40) | SLC6A4SLC6A2SLC6A3TACR1CYP1A2 | |
| SCHEMBL20844683 | 0.72 | SLC6A4 (0.41) | SLC6A4SLC6A2SLC6A3TACR1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110105526-A1 | SELECTIVE SUBTYPE ALPHA 2 ADRENERGIC AGENTS AND METHODS FOR USE THEREOF | ALLERGAN, INC. | 2011-05-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110105526-A1 | SELECTIVE SUBTYPE ALPHA 2 ADRENERGIC AGENTS AND METHODS FOR USE THEREOF | ADRB2, ADRA2C, ADRA2A | SLC6A4 231/4885SLC6A2 39/4885SLC6A3 215/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.