Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | PAOX | Q6QHF9 | 3/20 | 0.52 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.47 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.47 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.45 |
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.42 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.42 |
| ▸ | ZDHHC7 | Q9NXF8 | 1/20 | 0.41 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.41 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.41 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.40 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.39 |
| ▸ | RRM1 | P23921 | 1/20 | 0.39 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.39 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13567005 | 0.87 | KDM4E (0.54) | KDM4EMAPK1HIF1APAOXSIRT6 | |
| SCHEMBL13057117 | 0.84 | KDM4E (0.54) | KDM4EMAPK1HIF1APAOXSIRT6 | |
| SCHEMBL17193095 | 0.83 | PLA2G2C (0.60) | SIRT6SIRT1PLA2G2CPLA2G2AZDHHC7 | |
| SCHEMBL2666555 | 0.83 | PLA2G2C (0.60) | SIRT6SIRT1PLA2G2CPLA2G2AZDHHC7 | |
| SCHEMBL19412266 | 0.83 | PLA2G2C (0.60) | SIRT6SIRT1PLA2G2CPLA2G2AZDHHC7 | |
| SCHEMBL11506429 | 0.83 | PLA2G2C (0.59) | PLA2G2CPLA2G2ADPP7TAS1R3TAS1R1 | |
| SCHEMBL10033481 | 0.82 | TAS1R3 (0.50) | PLA2G2CADRA1APLA2G2ATAS1R3TAS1R1 | |
| SCHEMBL825197 | 0.79 | PAOX (0.49) | KDM4EMAPK1HIF1APAOXSIRT6 | |
| SCHEMBL6940595 | 0.79 | PLA2G2C (0.64) | SIRT6SIRT1PLA2G2CPLA2G2AZDHHC7 | |
| SCHEMBL11606057 | 0.79 | PLA2G2C (0.64) | SIRT6SIRT1PLA2G2CPLA2G2AZDHHC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8273343-B2 | Protein-polymer conjugates | PHARMAESSENTIA CORP. (TW) | 2012-09-25 | — | — | US | disclosed |
| US-20110098451-A1 | PEPTIDE-POLYMER CONJUGATES | PHARMAESSENTIA CORP. (TW) | 2011-04-28 | — | — | US | disclosed |
| US-20100029907-A1 | PEPTIDE-POLYMER CONJUGATES | PHARMAESSENTIA CORP. (TW) | 2010-02-04 | — | — | US | disclosed |
| US-20090017004-A1 | POLYMERIC DRUG DELIVERY SYSTEMS CONTAINING AN AROMATIC ALLYLIC ACID | ENZON PHARMACEUTICALS, INC. (US) | 2009-01-15 | — | — | US | disclosed |
| US-20090016985-A1 | POLYMERIC DRUG DELIVERY SYSTEM CONTAINING A MULTI-SUBSTITUTED AROMATIC MOIETY | ENZON PHARMACEUTICALS, INC. (US) | 2009-01-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029907-A1 | PEPTIDE-POLYMER CONJUGATES | IFNG, EPOR, IFNAR1 | KDM4E 4482/4885MAPK1 3789/4885HIF1A 115/4885 |
| US-20090017004-A1 | POLYMERIC DRUG DELIVERY SYSTEMS CONTAINING AN AROMATIC ALLYLIC ACID | AADAC, ACSS2, ANXA6 | KDM4E 1742/4885MAPK1 4791/4885HIF1A 1993/4885 |
| US-20110098451-A1 | PEPTIDE-POLYMER CONJUGATES | EPOR, NPPA, ENPEP | KDM4E 3758/4885MAPK1 3355/4885HIF1A 41/4885 |
| US-20090016985-A1 | POLYMERIC DRUG DELIVERY SYSTEM CONTAINING A MULTI-SUBSTITUTED AROMATIC MOIETY | ABCB1, PAICS, ABCG2 | KDM4E 430/4885MAPK1 4800/4885HIF1A 2527/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.