Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.44 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.42 |
| ▸ | OGG1 | O15527 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | THRB | P10828 | 2/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 9/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL126902 | 0.82 | CD274 (0.43) | LOXL2CD274OGG1ALDH1A1HPGD | |
| SCHEMBL660460 | 0.79 | LOXL2 (0.51) | LOXL2CD274OGG1ALDH1A1HPGD | |
| SCHEMBL6748902 | 0.76 | POLB (0.33) | ALDH1A1HPGDMEN1KMT2ACYP1A2 | |
| SCHEMBL6748905 | 0.72 | CYP2A6 (0.44) | LOXL2HDAC1HDAC8HDAC6CYP1A2 | |
| SCHEMBL11399086 | 0.72 | PLAAT3 (0.41) | ALDH1A1MAPTKMT2ANPC1RAB9A | |
| SCHEMBL18807670 | 0.72 | LOXL2 (0.56) | LOXL2CD274OGG1ALDH1A1HPGD | |
| SCHEMBL187684 | 0.71 | ALOX5 (0.51) | ALDH1A1HDAC8HDAC6LMNANPC1 | |
| SCHEMBL17921221 | 0.69 | LOXL2 (0.65) | LOXL2CD274OGG1ALDH1A1THRB | |
| SCHEMBL11389460 | 0.69 | F2RL1 (0.45) | ALDH1A1HDAC1HDAC8HDAC6MEN1 | |
| SCHEMBL11396194 | 0.68 | FFAR1 (0.45) | ALDH1A1HPGDTHRBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1390036-B1 | PROSTANOIC ACID DERIVATIVES AS AGENTS FOR LOWERING INTRAOCULAR PRESSURE | ALLERGAN INC (US) | 2012-03-07 | — | — | EP | disclosed |
| EP-1390036-A1 | PROSTANOIC ACID DERIVATIVES AS AGENTS FOR LOWERING INTRAOCULAR PRESSURE | Allergan, Inc. (US) | 2004-02-25 | — | — | EP | disclosed |
| US-6670485-B2 | Vision disorders | ALLERGAN, INC. | 2003-12-30 | — | — | US | disclosed |
| US-20030105155-A1 | Prostanoic acid derivatives as agents for lowering intraocular pressure | ALLERGAN SALES, INC. | 2003-06-05 | — | — | US | disclosed |
| US-6531504-B2 | Such as (Z)-7-((1R,2R,3R)-2-((E)-(S)-5-(3-Chlorobenzo(b) thiophen-2-yl)-3-hydroxypent-1-enyl)-3-hydroxy-5-oxocyclopentyl)hept-5-enoic acid for treatment of hypertension and/or glaucoma | ALLERGAN, INC. | 2003-03-11 | — | — | US | disclosed |
| US-20020177620-A1 | Prostanoic acid derivatives as agents for lowering intraocular pressure | ALLERGAN SALES, INC. | 2002-11-28 | — | — | US | disclosed |
| WO-2002092099-A1 | PROSTANOIC ACID DERIVATIVES AS AGENTS FOR LOWERING INTRAOCULAR PRESSURE | ALLERGAN, INC. (US) | 2002-11-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020177620-A1 | Prostanoic acid derivatives as agents for lowering intraocular pressure | PTGIR, PTGS2, CBR1 | LOXL2 420/4885CD274 4236/4885OGG1 1489/4885 |
| US-20030105155-A1 | Prostanoic acid derivatives as agents for lowering intraocular pressure | PTGIR, PTGS2, CBR1 | LOXL2 411/4885CD274 4241/4885OGG1 1476/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.