Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 2/20 | 0.52 |
| ▸ | TOP2A | P11388 | 1/20 | 0.52 |
| ▸ | STK17B | O94768 | 4/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.45 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | CRHBP | P24387 | 1/20 | 0.44 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12696418 | 0.80 | MAPT (0.68) | TOP1TOP2ASTK17BHDAC3HDAC4 | |
| SCHEMBL12694954 | 0.74 | STK17B (0.69) | STK17BHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL4261090 | 0.73 | TOP1 (0.75) | TOP1TOP2ASTK17BHDAC3HDAC4 | |
| SCHEMBL4261091 | 0.73 | TOP1 (0.75) | TOP1TOP2ASTK17BHDAC3HDAC4 | |
| SCHEMBL13643390 | 0.71 | TUBB1 (0.57) | ALDH1A1MAPTKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL30429737 | 0.71 | ACHE (0.68) | TOP1TOP2AALDH1A1MAPTKMT2A | |
| SCHEMBL4261109 | 0.71 | HDAC3 (0.52) | TOP1TOP2ASTK17BHDAC3HDAC4 | |
| SCHEMBL4261116 | 0.71 | HDAC3 (0.52) | TOP1TOP2ASTK17BHDAC3HDAC4 | |
| SCHEMBL4262064 | 0.70 | TOP1 (0.54) | TOP1TOP2ASTK17BHDAC3HDAC4 | |
| SCHEMBL4262061 | 0.70 | TOP1 (0.54) | TOP1TOP2ASTK17BHDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9567305-B2 | Quinoxaline compounds and derivatives | SOUTHERN METHODIST UNIVERSITY (US) | 2017-02-14 | — | — | US | disclosed |
| US-20140135494-A1 | Quinoxaline Compounds and Derivatives | SOUTHERN METHODIST UNIVERSITY (US) | 2014-05-15 | — | — | US | disclosed |
| US-8669363-B2 | Quinoxaline compounds and derivatives | SOUTHERN METHODIST UNIVERSITY (US) | 2014-03-11 | — | — | US | disclosed |
| US-20120245352-A1 | Quinoxaline Compounds and Derivatives | SOUTHERN METHODIST UNIVERSITY (US) | 2012-09-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140135494-A1 | Quinoxaline Compounds and Derivatives | CYP3A5, PDXK, QDPR | TOP1 63/4885TOP2A 55/4885STK17B 1252/4885 |
| US-20120245352-A1 | Quinoxaline Compounds and Derivatives | CYP3A5, PDXK, QDPR | TOP1 63/4885TOP2A 55/4885STK17B 1252/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.