Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.68 |
| ▸ | MEN1 | O00255 | 3/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.68 |
| ▸ | CRHBP | P24387 | 1/20 | 0.68 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.68 |
| ▸ | MAOB | P27338 | 1/20 | 0.60 |
| ▸ | TOP1 | P11387 | 1/20 | 0.58 |
| ▸ | TOP2A | P11388 | 1/20 | 0.58 |
| ▸ | F2 | P00734 | 1/20 | 0.55 |
| ▸ | STK17B | O94768 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12696424 | 0.82 | STK17B (0.79) | MAPTALDH1A1MEN1KMT2ACRHBP | |
| SCHEMBL29601681 | 0.81 | MAPT (0.82) | MAPTALDH1A1MEN1KMT2ACRHBP | |
| SCHEMBL12694947 | 0.80 | TOP1 (0.52) | MAPTALDH1A1MEN1KMT2ACRHBP | |
| SCHEMBL30429737 | 0.78 | ACHE (0.68) | MAPTALDH1A1MEN1KMT2AMAOB | |
| SCHEMBL4261090 | 0.78 | TOP1 (0.75) | ALDH1A1MEN1KMT2ATOP1TOP2A | |
| SCHEMBL4261091 | 0.78 | TOP1 (0.75) | ALDH1A1MEN1KMT2ATOP1TOP2A | |
| SCHEMBL4261116 | 0.76 | HDAC3 (0.52) | MAPTALDH1A1MEN1KMT2ATOP1 | |
| SCHEMBL4261109 | 0.76 | HDAC3 (0.52) | MAPTALDH1A1MEN1KMT2ATOP1 | |
| SCHEMBL1078524 | 0.75 | TOP1 (0.66) | ALDH1A1MEN1KMT2AMAOBTOP1 | |
| SCHEMBL4262064 | 0.75 | TOP1 (0.54) | MAPTALDH1A1MEN1KMT2ACRHBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9567305-B2 | Quinoxaline compounds and derivatives | SOUTHERN METHODIST UNIVERSITY (US) | 2017-02-14 | — | — | US | disclosed |
| US-20140135494-A1 | Quinoxaline Compounds and Derivatives | SOUTHERN METHODIST UNIVERSITY (US) | 2014-05-15 | — | — | US | disclosed |
| US-8669363-B2 | Quinoxaline compounds and derivatives | SOUTHERN METHODIST UNIVERSITY (US) | 2014-03-11 | — | — | US | disclosed |
| US-20120245352-A1 | Quinoxaline Compounds and Derivatives | SOUTHERN METHODIST UNIVERSITY (US) | 2012-09-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140135494-A1 | Quinoxaline Compounds and Derivatives | CYP3A5, PDXK, QDPR | MAPT 2893/4885ALDH1A1 1107/4885MEN1 1575/4885 |
| US-20120245352-A1 | Quinoxaline Compounds and Derivatives | CYP3A5, PDXK, QDPR | MAPT 2893/4885ALDH1A1 1107/4885MEN1 1575/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.