Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.35 |
| ▸ | POLB | P06746 | 3/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14788325 | 0.83 | ALDH1A1 (0.46) | ALDH1A1POLBTDP1KMT2AMEN1 | |
| SCHEMBL14788457 | 0.73 | C5AR1 (0.45) | ALDH1A1TDP1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL14788388 | 0.69 | GPX4 (0.49) | ALDH1A1POLBKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL29864762 | 0.69 | GPX4 (0.49) | ALDH1A1POLBKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL12469859 | 0.67 | ALDH1A1 (0.40) | ALDH1A1POLBTDP1KMT2AMEN1 | |
| SCHEMBL12696372 | 0.66 | ATM (0.45) | ALDH1A1KMT2AMEN1SMN1; SMN2HTT | |
| SCHEMBL523291 | 0.66 | APLNR (0.63) | ALDH1A1POLBTDP1KMT2AMEN1 | |
| SCHEMBL23888492 | 0.65 | ALDH1A1 (0.44) | ALDH1A1POLBTDP1KMT2AMEN1 | |
| SCHEMBL27702847 | 0.64 | CNR1 (0.51) | ALDH1A1POLBTDP1KMT2AMEN1 | |
| SCHEMBL30482840 | 0.62 | ALDH1A1 (0.53) | ALDH1A1POLBTDP1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012129452-A2 | PROPYNOIC ACID CARBAMOYL METHYL-ALMIDES AND PHARMACEUTICAL COMPOSITIONS AND METHODS BASED THEREON | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2012-09-27 | — | — | WO | disclosed |