Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.38 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14788609 | 0.78 | GAA (0.43) | GAASMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL14788457 | 0.78 | C5AR1 (0.45) | SMN1; SMN2MEN1KMT2AALDH1A1HTT | |
| SCHEMBL14788566 | 0.76 | MEN1 (0.66) | SMN1; SMN2RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL29864762 | 0.75 | GPX4 (0.49) | GAASMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL14788388 | 0.75 | GPX4 (0.49) | GAASMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL14788325 | 0.71 | ALDH1A1 (0.46) | SMN1; SMN2MEN1KMT2AALDH1A1HTT | |
| SCHEMBL14786950 | 0.69 | KEAP1 (0.39) | SMN1; SMN2MEN1KMT2AALDH1A1HTT | |
| SCHEMBL9833231 | 0.68 | PPARG (0.46) | GAANPC1RAB9AMEN1KMT2A | |
| SCHEMBL11217828 | 0.67 | PDK2 (0.47) | GAASMN1; SMN2RAB9AMEN1KMT2A | |
| SCHEMBL14788482 | 0.66 | LMNA (0.42) | GAASMN1; SMN2NPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130071328-A1 | Propynoic Acid Carbamoyl Methyl-Amides and Pharmaceutical Compositions and Methods Based Thereon | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2013-03-21 | — | — | US | disclosed |
| WO-2012129452-A2 | PROPYNOIC ACID CARBAMOYL METHYL-ALMIDES AND PHARMACEUTICAL COMPOSITIONS AND METHODS BASED THEREON | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2012-09-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130071328-A1 | Propynoic Acid Carbamoyl Methyl-Amides and Pharmaceutical Compositions and Methods Based Thereon | RELA, NFE2, NCOA1 | ATM 2199/4885GAA 2437/4885SMN1; SMN2 3101/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.