Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NT5E | P21589 | 1/20 | 0.61 |
| ▸ | TGM2 | P21980 | 1/20 | 0.59 |
| ▸ | IMPDH2 | P12268 | 6/20 | 0.56 |
| ▸ | KRAS | P01116 | 8/20 | 0.55 |
| ▸ | IMPDH1 | P20839 | 2/20 | 0.54 |
| ▸ | FUT5 | Q11128 | 1/20 | 0.54 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.52 |
| ▸ | P2RY4 | P51582 | 1/20 | 0.52 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.52 |
| ▸ | HINT1 | P49773 | 1/20 | 0.51 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.51 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8582691 | 0.93 | NT5E (0.59) | NT5ETGM2IMPDH2KRASIMPDH1 | |
| SCHEMBL180928 | 0.92 | NT5E (0.61) | NT5ETGM2IMPDH2KRASIMPDH1 | |
| SCHEMBL1235770 | 0.92 | NT5E (0.61) | NT5ETGM2IMPDH2KRASIMPDH1 | |
| SCHEMBL5061620 | 0.88 | NT5E (0.60) | NT5ETGM2IMPDH2KRASIMPDH1 | |
| SCHEMBL7571229 | 0.88 | NT5E (0.60) | NT5ETGM2IMPDH2KRASIMPDH1 | |
| Demannose SCHEMBL2182862 | 0.88 | TGM2 (0.66) | NT5ETGM2IMPDH2KRASIMPDH1 | |
| Galactose SCHEMBL6046113 | 0.88 | TGM2 (0.66) | NT5ETGM2IMPDH2KRASIMPDH1 | |
| Demannose SCHEMBL4290630 | 0.88 | TGM2 (0.66) | NT5ETGM2IMPDH2KRASIMPDH1 | |
| Demannose SCHEMBL20746287 | 0.88 | TGM2 (0.66) | NT5ETGM2IMPDH2KRASIMPDH1 | |
| Demannose SCHEMBL5163477 | 0.88 | TGM2 (0.66) | NT5ETGM2IMPDH2KRASIMPDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8849577-B2 | Methods of identifying biochemical pathways | METABOLON, INC. (US) | 2014-09-30 | — | — | US | disclosed |
| EP-1582581-B1 | Saccharide composition synthesizer | HITACHI HIGH TECH CORP (JP) | 2013-07-03 | — | — | EP | disclosed |
| US-8435763-B2 | from cultures of microorganisms in the presence of enzymes; used for immunotherapy, preventing bacterial or viral infections and treating cardiovascular disorders | KYOWA HAKKO BIO CO., LTD. (JP) | 2013-05-07 | — | — | US | disclosed |
| US-8232079-B2 | Oligosaccharide synthesizer | HITACHI HIGH-TECHNOLOGIES CORPORATION (JP) | 2012-07-31 | — | — | US | disclosed |
| EP-1422290-B1 | Apparatus for oligosaccharide synthesis | HITACHI HIGH TECH CORP (JP) | 2011-06-15 | — | — | EP | disclosed |
| US-7883873-B2 | sugar chain synthesizer capable of continuously reacting sugar chains when a plurality of sugar chains are successively reacted; includes a plurality of vessels containing respective sugar nucleotide solutions, a plurality of vessels containing respective glycosyltransferases, and a reactor | HITACHI HIGH-TECHNOLOGIES CORPORATION (JP) | 2011-02-08 | — | — | US | disclosed |
| US-7700701-B2 | Water-soluble polymer compound having sugar chains | TOYO BOSEKI KABUSHIKI KAISHA (JP) | 2010-04-20 | — | — | US | disclosed |
| US-20080161228-A1 | Using metabolomics to expedite drug discovery and development; invention provides means to select and advance most selective lead compounds from series of candidates based on metabolomic profiles which contain data regarding both expected or intended (e.g., on-target) and unexpected effects of compounds | METABOLON INC. (US) | 2008-07-03 | — | — | US | disclosed |
| WO-2008033575-A9 | METHODS OF IDENTIFYING BIOCHEMICAL PATHWAYS | METABOLON INC (US) | 2008-06-26 | — | — | WO | disclosed |
| WO-2008033575-A2 | METHODS OF IDENTIFYING BIOCHEMICAL PATHWAYS | METABOLON, INC. (US) | 2008-03-20 | — | — | WO | disclosed |
| US-20030119090-A1 | Mannosyl transfer with regeneration of GDP-mannose | WONG CHI-HUEY (US) | 2003-06-26 | — | — | US | disclosed |
| US-6485930-B1 | Mannosyl transfer with regeneration of GDP-mannose | THE SCRIPPS RESEARCH INSTITUTE | 2002-11-26 | — | — | US | disclosed |
| US-20020068331-A1 | Production of fucosylated carbohydrates by enzymatic fucosylation synthesis of sugar nucleotides; and in situ regeneration of GDP-fucose | WONG CHI-HUEY (US) | 2002-06-06 | — | — | US | disclosed |
| US-6319695-B1 | FORMING A GLYCOSIDE BOND BY ETHERIFICATION AND CIRCULATION | THE SCRIPPS RESEARCH INSITUTE | 2001-11-20 | — | — | US | disclosed |
| US-6046040-A | Method for producing glycoconjugates | TOYO BOSEKI KABUSHIKI KAISHA (JP) | 2000-04-04 | — | — | US | disclosed |
| EP-0642526-B1 | PRODUCTION OF FUCOSYLATED CARBOHYDRATES BY ENZYMATIC FUCOSYLATION SYNTHESIS OF SUGAR NUCLEOTIDES; AND IN SITU REGENERATION OF GDP-FUCOSE | SCRIPPS RESEARCH INST (US) | 1998-12-23 | — | — | EP | disclosed |
| EP-0870841-A1 | PROCESSES FOR PRODUCING SUGAR NUCLEOTIDES AND COMPLEX CARBOHYDRATES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1998-10-14 | — | — | EP | disclosed |
| EP-0642526-A4 | PRODUCTION OF FUCOSYLATED CARBOHYDRATES BY ENZYMATIC FUCOSYLATION SYNTHESIS OF SUGAR NUCLEOTIDES; AND IN SITU REGENERATION OF GDP-FUCOSE. | SCRIPPS RESEARCH INST (US) | 1996-04-10 | — | — | EP | disclosed |
| EP-0642526-A1 | PRODUCTION OF FUCOSYLATED CARBOHYDRATES BY ENZYMATIC FUCOSYLATION SYNTHESIS OF SUGAR NUCLEOTIDES; AND IN SITU REGENERATION OF GDP-FUCOSE | THE SCRIPPS RESEARCH INSTITUTE (US) | 1995-03-15 | — | — | EP | disclosed |
| WO-1993008205-A1 | PRODUCTION OF FUCOSYLATED CARBOHYDRATES BY ENZYMATIC FUCOSYLATION SYNTHESIS OF SUGAR NUCLEOTIDES; AND IN SITU REGENERATION OF GDP-FUCOSE | THE SCRIPPS RESEARCH INSTITUTE (US) | 1993-04-29 | — | — | WO | disclosed |