Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.69 |
| ▸ | KLKB1 | P03952 | 4/20 | 0.64 |
| ▸ | PLG | P00747 | 5/20 | 0.61 |
| ▸ | KLK1 | P06870 | 5/20 | 0.61 |
| ▸ | KLK6 | Q92876 | 5/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | GFER | P55789 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.54 |
| ▸ | APEX1 | P27695 | 1/20 | 0.54 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17538569 | 0.86 | ALDH1A1 (0.63) | ALDH1A1PLGKLK1KLK6KMT2A | |
| SCHEMBL13927135 | 0.86 | ALDH1A1 (0.92) | ALDH1A1KMT2ACYP1A2MEN1GFER | |
| SCHEMBL16426269 | 0.85 | ALDH1A1 (0.71) | ALDH1A1KMT2ACYP1A2MEN1GFER | |
| SCHEMBL12615048 | 0.85 | ALDH1A1 (0.71) | ALDH1A1KMT2ACYP1A2MEN1GFER | |
| SCHEMBL16088650 | 0.85 | ALDH1A1 (0.61) | ALDH1A1KMT2ACYP1A2GFER | |
| SCHEMBL17538448 | 0.84 | ALDH1A1 (0.65) | ALDH1A1KMT2ACYP1A2MEN1GFER | |
| SCHEMBL4335299 | 0.84 | ALDH1A1 (0.69) | ALDH1A1KMT2ACYP1A2MEN1GFER | |
| SCHEMBL7829395 | 0.84 | ALDH1A1 (0.70) | ALDH1A1KMT2ACYP1A2MEN1GFER | |
| SCHEMBL4322720 | 0.84 | ALDH1A1 (0.69) | ALDH1A1KMT2ACYP1A2MEN1GFER | |
| SCHEMBL18132588 | 0.84 | FFAR1 (0.73) | ALDH1A1KMT2ACYP1A2MEN1GFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10166237-B2 | Compounds and methods for inducing chondrogenesis | THE SCRIPPS RESEARCH INSTITUTE (US) | 2019-01-01 | — | — | US | disclosed |
| US-20170112843-A1 | COMPOUNDS AND METHODS FOR INDUCING CHONDROGENESIS | THE SCRIPPS RESEARCH INSTITUTE | 2017-04-27 | — | — | US | disclosed |
| US-20170112843-A1 | COMPOUNDS AND METHODS FOR INDUCING CHONDROGENESIS | THE SCRIPPS RESEARCH INSTITUTE | 2017-04-27 | — | — | US | disclosed |
| US-9464065-B2 | Compounds and methods for inducing chondrogenesis | THE SCRIPPS RESEARCH INSTITUTE (US) | 2016-10-11 | — | — | US | disclosed |
| US-9464065-B2 | Compounds and methods for inducing chondrogenesis | THE SCRIPPS RESEARCH INSTITUTE (US) | 2016-10-11 | — | — | US | disclosed |
| WO-2012129562-A2 | COMPOUNDS AND METHODS FOR INDUCING CHONDROGENESIS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2012-09-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10166237-B2 | Compounds and methods for inducing chondrogenesis | COL2A1, BMP4, BMP2 | ALDH1A1 63/4885KLKB1 3672/4885PLG 1902/4885 |
| US-20170112843-A1 | COMPOUNDS AND METHODS FOR INDUCING CHONDROGENESIS | COL2A1, BMP4, BMP2 | ALDH1A1 63/4885KLKB1 3672/4885PLG 1902/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.