Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CFD | P00746 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | PLG | P00747 | 1/20 | 0.50 |
| ▸ | KLK1 | P06870 | 1/20 | 0.50 |
| ▸ | KLK6 | Q92876 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18132586 | 0.87 | ALDH1A1 (0.65) | ALDH1A1KMT2AMEN1HTTCYP1A2 | |
| SCHEMBL12700210 | 0.86 | ALDH1A1 (0.69) | ALDH1A1KMT2AMEN1CYP1A2CYP3A4 | |
| SCHEMBL27484183 | 0.85 | FADS1 (0.60) | ALDH1A1AURKBCFDPLGKLK1 | |
| SCHEMBL13927138 | 0.84 | ALDH1A1 (0.81) | ALDH1A1KMT2AMEN1HTTCYP1A2 | |
| SCHEMBL23367948 | 0.84 | SMN1; SMN2 (0.68) | ALDH1A1KMT2AMEN1AURKB | |
| SCHEMBL27952999 | 0.84 | AURKB (0.56) | ALDH1A1AURKBCFDPLGKLK1 | |
| SCHEMBL6681834 | 0.83 | KCNK3 (0.69) | KMT2AMEN1CFD | |
| SCHEMBL17538575 | 0.83 | ALDH1A1 (0.63) | ALDH1A1KMT2AMEN1HTTCYP1A2 | |
| SCHEMBL27795055 | 0.83 | PLG (0.60) | KMT2AMEN1AURKBPLGKLK1 | |
| SCHEMBL12700341 | 0.83 | KMT2A (0.63) | ALDH1A1KMT2AMEN1HTTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2968330-B1 | COMPOUNDS AND METHODS FOR INDUCING CHONDROGENESIS | SCRIPPS RESEARCH INST (US) | 2021-09-29 | — | — | EP | disclosed |
| US-11045476-B2 | Compounds and methods for inducing chondrogenesis | THE SCRIPPS RESEARCH INSTITUTE (US) | 2021-06-29 | — | — | US | disclosed |
| US-20200188407-A1 | COMPOUNDS AND METHODS FOR INDUCING CHONDROGENESIS | THE SCRIPPS RESEARCH INSTITUTE | 2020-06-18 | — | — | US | disclosed |
| US-9452170-B2 | Compounds and methods for inducing chondrogenesis | THE CALIFORNIA INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2016-09-27 | — | — | US | disclosed |
| US-20160045514-A1 | COMPOUNDS AND METHODS FOR INDUCING CHONDROGENESIS | THE CALIFORNIA INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2016-02-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11045476-B2 | Compounds and methods for inducing chondrogenesis | COL2A1, BMP4, COL1A1 | ALDH1A1 52/4885KMT2A 3871/4885MEN1 4679/4885 |
| US-20160045514-A1 | COMPOUNDS AND METHODS FOR INDUCING CHONDROGENESIS | COL2A1, BMP4, COL1A1 | ALDH1A1 52/4885KMT2A 3871/4885MEN1 4679/4885 |
| US-20200188407-A1 | COMPOUNDS AND METHODS FOR INDUCING CHONDROGENESIS | COL2A1, BMP4, COL1A1 | ALDH1A1 52/4885KMT2A 3871/4885MEN1 4679/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.