Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | NQO2 | P16083 | 4/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.38 |
| ▸ | TUBB | P07437 | 1/20 | 0.38 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.38 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.38 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29592465 | 1.00 | KDM4E (0.54) | KDM4ESMN1; SMN2ALDH1A1NPC1MAPT | |
| SCHEMBL31267853 | 0.83 | L3MBTL1 (0.41) | KDM4ESMN1; SMN2ALDH1A1NPC1MAPT | |
| SCHEMBL16761769 | 0.83 | KDM4E (0.49) | KDM4ESMN1; SMN2ALDH1A1NPC1MAPT | |
| SCHEMBL1579279 | 0.83 | ALDH1A1 (0.47) | KDM4ESMN1; SMN2ALDH1A1NPC1MAPT | |
| SCHEMBL30416311 | 0.83 | ALDH1A1 (0.47) | KDM4ESMN1; SMN2ALDH1A1NPC1MAPT | |
| SCHEMBL25343847 | 0.82 | KDM4E (0.54) | KDM4ESMN1; SMN2ALDH1A1NPC1MAPT | |
| SCHEMBL8606526 | 0.82 | KDM4E (0.54) | KDM4ESMN1; SMN2ALDH1A1NPC1MAPT | |
| SCHEMBL31729407 | 0.81 | KDM4E (0.56) | KDM4ESMN1; SMN2ALDH1A1NPC1MAPT | |
| SCHEMBL21349700 | 0.81 | KDM4E (0.53) | KDM4ESMN1; SMN2ALDH1A1NPC1MAPT | |
| SCHEMBL31729133 | 0.81 | KDM4E (0.56) | KDM4ESMN1; SMN2ALDH1A1NPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3484882-B1 | ISO-CITRATE DEHYDROGENASE (IDH) INHIBITOR | ZHEJIANG METON PHARMACEUTICAL CO LTD (CN) | 2022-04-27 | — | — | EP | disclosed |
| CN-109641890-B | Isocitrate Dehydrogenase (IDH) inhibitors | 浙江迈同生物医药有限公司 | 2022-04-26 | — | — | CN | disclosed |
| US-10752626-B2 | Iso-citrate dehydrogenase (IDH) inhibitor | SHANGHAI METON PHARMACEUTICAL CO., LTD (CN) | 2020-08-25 | — | — | US | disclosed |
| US-20190256511-A1 | ISO-CITRATE DEHYDROGENASE (IDH) INHIBITOR | ZHEJIANG METON PHARMACEUTICAL CO., LTD (CN) | 2019-08-22 | — | — | US | disclosed |
| US-20110092505-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2011-04-21 | — | — | US | disclosed |
| US-20110092505-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2011-04-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190256511-A1 | ISO-CITRATE DEHYDROGENASE (IDH) INHIBITOR | IDH3A, IDH2, IDH1 | KDM4E 626/4885SMN1; SMN2 3374/4885ALDH1A1 499/4885 |
| US-10752626-B2 | Iso-citrate dehydrogenase (IDH) inhibitor | IDH3A, IDH2, IDH1 | KDM4E 626/4885SMN1; SMN2 3374/4885ALDH1A1 499/4885 |
| US-20110092505-A1 | ORGANIC COMPOUNDS | SLCO2B1, SLCO1B1, SLCO1B3 | KDM4E 3921/4885SMN1; SMN2 3700/4885ALDH1A1 93/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.