Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | NQO2 | P16083 | 6/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.38 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.38 |
| ▸ | TUBB | P07437 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21349340 | 0.85 | KDM4E (0.51) | KDM4ESMN1; SMN2ALDH1A1ABL1NQO2 | |
| SCHEMBL21349339 | 0.85 | KDM4E (0.47) | KDM4ESMN1; SMN2ALDH1A1ABL1NQO2 | |
| SCHEMBL21348932 | 0.83 | ALDH1A1 (0.50) | KDM4ESMN1; SMN2ALDH1A1ABL1NQO2 | |
| SCHEMBL31320124 | 0.83 | ALDH1A1 (0.50) | KDM4ESMN1; SMN2ALDH1A1ABL1NQO2 | |
| SCHEMBL110643 | 0.83 | KDM4E (0.53) | KDM4ESMN1; SMN2ALDH1A1ABL1NQO2 | |
| SCHEMBL29678780 | 0.83 | KDM4E (0.53) | KDM4ESMN1; SMN2ALDH1A1ABL1NQO2 | |
| SCHEMBL28906480 | 0.82 | PLA2G2A (0.40) | KDM4ESMN1; SMN2ALDH1A1ABL1NQO2 | |
| SCHEMBL25343847 | 0.81 | KDM4E (0.54) | KDM4ESMN1; SMN2ALDH1A1ABL1NQO2 | |
| SCHEMBL12701205 | 0.81 | KDM4E (0.54) | KDM4ESMN1; SMN2ALDH1A1ABL1NQO2 | |
| SCHEMBL8606526 | 0.81 | KDM4E (0.54) | KDM4ESMN1; SMN2ALDH1A1ABL1NQO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025264818-A1 | STAT6 MODULATORS AND METHODS OF USES THEREOF | RAYTHERA, INC. (US) | 2025-12-26 | — | — | WO | disclosed |
| CN-110950868-B | Pyrazolopyrimidine compound, preparation method thereof and application of pyrazolopyrimidine compound in preparation of anti-cancer drugs | 苏州锐明新药研发有限公司 | 2022-05-13 | — | — | CN | disclosed |
| US-10947242-B2 | [1,2,4]triazolo[1,5and#8208;A]pyrimidine compounds as PDE2 inhibitors | JANSSEN PHARMACEUTICA, NV (BE) | 2021-03-16 | — | — | US | disclosed |
| EP-3535267-B1 | [1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE DERIVATIVES AS PDE2 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-12-30 | — | — | EP | disclosed |
| CN-110950868-A | Pyrazolopyrimidine compound, preparation method thereof and application thereof in preparing anti-cancer drugs | 苏州锐明新药研发有限公司 | 2020-04-03 | — | — | CN | disclosed |
| US-20190276462-A1 | [1,2,4]TRIAZOLO[1,5‐A]PYRIMIDINE COMPOUNDS AS PDE2 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2019-09-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190276462-A1 | [1,2,4]TRIAZOLO[1,5‐A]PYRIMIDINE COMPOUNDS AS PDE2 INHIBITORS | PDE2A, PDE12, PDE5A | KDM4E 1504/4885SMN1; SMN2 800/4885ALDH1A1 404/4885 |
| US-10947242-B2 | [1,2,4]triazolo[1,5and#8208;A]pyrimidine compounds as PDE2 inhibitors | PDE2A, PDE12, PDE5A | KDM4E 1414/4885SMN1; SMN2 785/4885ALDH1A1 317/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.