Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 1/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.49 |
| ▸ | GAA | P10253 | 7/20 | 0.49 |
| ▸ | MAPT | P10636 | 7/20 | 0.49 |
| ▸ | HPGD | P15428 | 4/20 | 0.49 |
| ▸ | THRB | P10828 | 3/20 | 0.49 |
| ▸ | GFER | P55789 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | PLEC | Q15149 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | NNMT | P40261 | 1/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.43 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14190740 | 0.85 | PRKCI (0.53) | PRKCIKDM4EALDH1A1GAAGLA | |
| SCHEMBL1067119 | 0.85 | PRKCI (0.73) | PRKCIKDM4EALDH1A1GAAMAPT | |
| SCHEMBL2245773 | 0.85 | PRKCI (1.00) | PRKCIKDM4EALDH1A1GAAMAPT | |
| SCHEMBL2248152 | 0.83 | PRKCI (0.71) | PRKCIKDM4EALDH1A1GAAMAPT | |
| SCHEMBL18833886 | 0.83 | PRKCI (0.71) | PRKCIKDM4EALDH1A1GAAMAPT | |
| Hydrochloric Acid SCHEMBL18691959 | 0.83 | PRKCI (0.71) | PRKCIKDM4EALDH1A1GAAMAPT | |
| SCHEMBL10600114 | 0.81 | PRKCI (0.54) | PRKCIKDM4EALDH1A1GAAMAPT | |
| SCHEMBL542066 | 0.81 | PRKCI (0.69) | PRKCIKDM4EALDH1A1GAAMAPT | |
| SCHEMBL18229474 | 0.81 | PRKCI (0.69) | PRKCIKDM4EALDH1A1GAAMAPT | |
| SCHEMBL27011562 | 0.81 | PRSS1 (0.66) | PRKCIPRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10975287-B2 | Heterocyclic amides useful as protein modulators | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED | 2021-04-13 | — | — | US | disclosed |
| US-10975287-B2 | Heterocyclic amides useful as protein modulators | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED | 2021-04-13 | — | — | US | disclosed |
| US-20200325126-A1 | HETEROCYCLIC AMIDES USEFUL AS PROTEIN MODULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2020-10-15 | — | — | US | disclosed |
| US-20200325126-A1 | HETEROCYCLIC AMIDES USEFUL AS PROTEIN MODULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2020-10-15 | — | — | US | disclosed |
| EP-3440072-B1 | HETEROCYCLIC AMIDES USEFUL AS PROTEIN MODULATORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2020-01-29 | — | — | EP | disclosed |
| EP-3440072-B1 | HETEROCYCLIC AMIDES USEFUL AS PROTEIN MODULATORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2020-01-29 | — | — | EP | disclosed |
| CN-109563081-A | It can be used as the heterocycleamide class of protein modulators | 葛兰素史克知识产权开发有限公司 | 2019-04-02 | — | — | CN | disclosed |
| EP-3440072-A1 | HETEROCYCLIC AMIDES USEFUL AS PROTEIN MODULATORS | GlaxoSmithKline Intellectual Property Development Ltd (GB) | 2019-02-13 | — | — | EP | disclosed |
| WO-2017175156-A1 | HETEROCYCLIC AMIDES USEFUL AS PROTEIN MODULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2017-10-12 | — | — | WO | disclosed |
| WO-2017175156-A1 | HETEROCYCLIC AMIDES USEFUL AS PROTEIN MODULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2017-10-12 | — | — | WO | disclosed |
| US-20080153837-A1 | Novel Fluorene Derivatives, Composition Containing Said Derivatives and the Use Thereof | AVENTIS PHARMA S.A. (FR) | 2008-06-26 | — | — | US | disclosed |
| US-20080125358-A1 | Methods for Chk2 inhibitor patient selection | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 2008-05-29 | — | — | US | disclosed |
| US-20080125358-A1 | Methods for Chk2 inhibitor patient selection | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 2008-05-29 | — | — | US | disclosed |
| US-20070185173-A1 | Process for the Preparation of the Salts of 4-(Benzimidazolylmethylamino)-Benzamides | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-08-09 | — | — | US | disclosed |
| US-20070185333-A1 | Process for the Preparation of 4-(Benzimidazolylmethylamino)-Benzamides and the Salts Thereof | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-08-09 | — | — | US | disclosed |
| WO-2007071742-A1 | IMPROVED PROCESS FOR THE PREPARATION OF 4-(BENZIMIDAZOLYLMETHYLAMINO)-BENZAMIDES AND THE SALTS THEREOF | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-06-28 | — | — | WO | disclosed |
| WO-2007071743-A1 | IMPROVED PROCESS FOR THE PREPARATION OF THE SALTS OF 4-(BENZIMIDAZOLYLMETHYLAMINO)-BENZAMIDES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-06-28 | — | — | WO | disclosed |
| US-20070149589-A1 | Process for the Preparation of 4-(benzimidazolylmethylamino)benzamidines | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-06-28 | — | — | US | disclosed |
| US-7202368-B2 | Process for the preparation of 4-(benzimidazolymethylamino) benzamidines | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-04-10 | — | — | US | disclosed |
| US-20060004064-A1 | Process for the preparation of 4-(benzimidazolymethylamino) benzamidines | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2006-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200325126-A1 | HETEROCYCLIC AMIDES USEFUL AS PROTEIN MODULATORS | ARGLU1, G3BP1, G3BP2 | PRKCI 1089/4885KDM4E 2147/4885ALDH1A1 3445/4885 |
| US-10975287-B2 | Heterocyclic amides useful as protein modulators | ARGLU1, G3BP1, G3BP2 | PRKCI 1089/4885KDM4E 2147/4885ALDH1A1 3445/4885 |
| US-20070149589-A1 | Process for the Preparation of 4-(benzimidazolylmethylamino)benzamidines | DDC, PDK2, ACMSD | PRKCI 2861/4885KDM4E 1256/4885ALDH1A1 52/4885 |
| US-20070185173-A1 | Process for the Preparation of the Salts of 4-(Benzimidazolylmethylamino)-Benzamides | DDC, BCKDK, IL4I1 | PRKCI 2814/4885KDM4E 1219/4885ALDH1A1 55/4885 |
| US-20070185333-A1 | Process for the Preparation of 4-(Benzimidazolylmethylamino)-Benzamides and the Salts Thereof | DDC, BCKDK, ODC1 | PRKCI 2551/4885KDM4E 963/4885ALDH1A1 40/4885 |
| US-20060004064-A1 | Process for the preparation of 4-(benzimidazolymethylamino) benzamidines | DDC, PDK2, ACMSD | PRKCI 2973/4885KDM4E 852/4885ALDH1A1 68/4885 |
| US-20080125358-A1 | Methods for Chk2 inhibitor patient selection | CHEK2, CHEK1, TP53 | PRKCI 64/4885KDM4E 1930/4885ALDH1A1 3938/4885 |
| US-20080153837-A1 | Novel Fluorene Derivatives, Composition Containing Said Derivatives and the Use Thereof | HSP90B1, HSP90AB1, HSP90AA1 | PRKCI 830/4885KDM4E 3419/4885ALDH1A1 3050/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.