Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | PKM | P14618 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | FABP6 | P51161 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9763711 | 0.87 | PKM (0.74) | TDP1MAPK1ALDH1A1PKMPOLB | |
| Hydrochloric Acid SCHEMBL1596692 | 0.86 | PKM (0.72) | TDP1MAPK1ALDH1A1PKMPOLB | |
| SCHEMBL31329800 | 0.83 | MAPK1 (0.69) | TDP1MAPK1ALDH1A1PKMPOLB | |
| SCHEMBL14590536 | 0.83 | MAPK1 (0.69) | TDP1MAPK1ALDH1A1PKMPOLB | |
| SCHEMBL12225719 | 0.83 | MAPK1 (0.69) | TDP1MAPK1ALDH1A1PKMPOLB | |
| SCHEMBL10700296 | 0.83 | CHRM2 (0.57) | TDP1MAPK1ALDH1A1PKMPOLB | |
| SCHEMBL31350725 | 0.83 | TDP1 (0.78) | TDP1MAPK1ALDH1A1PKMKMT2A | |
| SCHEMBL12706341 | 0.83 | ALDH1A1 (0.60) | ALDH1A1POLBMEN1KMT2AGAA | |
| SCHEMBL28872461 | 0.82 | TDP1 (0.58) | TDP1MAPK1ALDH1A1PKMPOLB | |
| SCHEMBL22702163 | 0.81 | PKM (0.66) | TDP1MAPK1ALDH1A1PKMPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7919517-B2 | Indazole derivatives | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2011-04-05 | — | — | US | disclosed |
| US-20090082348-A1 | INDAZOLE DERIVATIVES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2009-03-26 | — | — | US | disclosed |
| US-7470717-B2 | Indazole derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2008-12-30 | — | — | US | disclosed |
| US-20070117856-A1 | Indazole derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2007-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070117856-A1 | Indazole derivatives | IGF1R, NR0B2, ADRA2B | TDP1 4777/4885MAPK1 1618/4885ALDH1A1 1193/4885 |
| US-20090082348-A1 | INDAZOLE DERIVATIVES | IGF1R, NR0B2, ADRA2B | TDP1 4777/4885MAPK1 1618/4885ALDH1A1 1193/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.