Sugi Predict

Sugi Predict / Compounds / SCHEMBL127092

SCHEMBL127092

SCHEMBL127092

FC(F)(Br)c1ccccc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 3/20 0.61
▸ TSHR P16473 2/20 0.61
▸ PTPN1 P18031 2/20 0.46
▸ KCNN4 O15554 3/20 0.45
▸ CA1 P00915 1/20 0.44
▸ CA2 P00918 1/20 0.44
▸ CA5A P35218 1/20 0.44
▸ CA9 Q16790 1/20 0.44
▸ KIF11 P52732 1/20 0.43
▸ MAPK1 P28482 1/20 0.39
▸ PGK1 P00558 1/20 0.37
▸ PGK2 P07205 1/20 0.37
▸ TDP1 Q9NUW8 1/20 0.37
▸ BACE1 P56817 1/20 0.37
▸ CYP1A2 P05177 1/20 0.36
▸ TAAR1 Q96RJ0 1/20 0.36
▸ ALOX15 P16050 1/20 0.36
▸ CES1 P23141 1/20 0.36
▸ TRPV6 Q9H1D0 1/20 0.36
▸ PTPN5 P54829 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9069660 0.84 TSHR (0.46) ALDH1A1TSHRPTPN1KCNN4CA1
SCHEMBL25119686 0.83 KIF11 (0.68) ALDH1A1TSHRPTPN1CA1CA2
SCHEMBL927399 0.82 ALDH1A1 (0.37) ALDH1A1TSHRPTPN1CA1CA2
SCHEMBL10873447 0.80 ALDH1A1 (0.61) ALDH1A1TSHRPTPN1KCNN4CA1
SCHEMBL21647231 0.79 ALDH1A1 (0.50) ALDH1A1TSHRPTPN1KCNN4MAPK1
SCHEMBL25119879 0.77 APP (0.55) ALDH1A1TSHRPTPN1CA1CA2
Trifluoromethylbenzene SCHEMBL175647 0.76 TSHR (1.00) ALDH1A1TSHRPTPN1KCNN4CA1
SCHEMBL1108511 0.76 TSHR (0.65) ALDH1A1TSHRPTPN1KCNN4CA1
Trifluoromethylbenzene SCHEMBL8692 0.76 TSHR (1.00) ALDH1A1TSHRPTPN1KCNN4CA1
SCHEMBL1538909 0.76 TSHR (0.65) ALDH1A1TSHRPTPN1KCNN4CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 202 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103539632-B Method for preparing octafluoro [2,2] dimeric p-xylene by catalysis YUAN-SHIN MATERIALS TECHNOLOGY CORP. (CN) 2016-01-20 — — CN claimed
CN-104876794-A Method for preparing octafluoro [2,2] dimeric p-xylene by illumination YUAN SHIN MATERIALS TECHNOLOGY CORP 2015-09-02 — — CN claimed
CN-103539632-A Method for preparing octafluoro [2,2] dimeric p-xylene by catalysis or illumination YUAN SHIN MATERIALS TECHNOLOGY CORP LTD 2014-01-29 — — CN claimed
US-20090065345-A1 METHOD AND DEVICE FOR PURIFYING 1,4-BIS (BROMODIFLUOROMETHYL) BENZENE CHUNG SHAN INSTITUTE OF SCIENCE AND TECHNOLOGY (TW) 2009-03-12 — — US claimed
US-4059610-A Process for preparing isocyanic acid derivatives KAO SOAP CO., LTD. (JA) 1977-11-22 — — US claimed
US-20260109696-A1 SMALL MOLECULE PROTEIN SYNTHESIS MODULATORS Interdict Bio, Inc. (US) 2026-04-23 — — US disclosed
US-20260078116-A1 SMALL MOLECULE PROTEIN SYNTHESIS MODULATORS Interdict Bio, Inc. (US) 2026-03-19 — — US disclosed
US-12338241-B2 Bicyclic sulfones and sulfoxides and methods of use thereof GENENTECH, INC. (US) 2025-06-24 — — US disclosed
CN-119059929-A Synthesis method of fluoroalkyl amine compound 中国科学院上海有机化学研究所 2024-12-03 — — CN disclosed
CN-111278809-B Bicyclic sulfones and sulfoxides, and methods of use thereof 豪夫迈·罗氏有限公司 2024-06-25 — — CN disclosed
CN-111989321-B KRAS G12C inhibitors 米拉蒂治疗股份有限公司 2024-05-14 — — CN disclosed
CN-117460731-A Heterocyclic lactams, process for their preparation and their use in medicine 劲方医药科技(上海)有限公司 2024-01-26 — — CN disclosed
EP-0092628-B1 PROCESS FOR THE PREPARATION OF PHENYL KETONES STARTING FROM HALOGEN OR TRIHALOGEN METHYL BENZENES AND ALIPHATIC OR AROMATIC TRIHALOGEN-METHYL COMPOUNDS RHONE-POULENC SPECIALITES CHIMIQUES (FR) 1985-05-29 — — EP disclosed
EP-0084742-B1 PROCESS FOR THE ACYLATION OF HALOGEN OR TRIHALOGEN METHYL BENZENES RHONE-POULENC SPECIALITES CHIMIQUES (FR) 1985-05-22 — — EP disclosed
US-4454350-A Process for the acylation of halo- or trihalomethylbenzenes RHONE-POULENC SPECIALITIES CHIMIQUES (FR) 1984-06-12 — — US disclosed
US-4453012-A REACTION OF A HALO OR TRIHALOMETHYL BENZENE WITH A TRIHALOMETHYLATED ALIPHATIC OR AROMATIC COMPOUND RHONE-POULENC SPECIALITES CHIMIQUES (FR) 1984-06-05 — — US disclosed
EP-0092628-A1 Process for the preparation of phenyl ketones starting from halogen or trihalogen methyl benzenes and aliphatic or aromatic trihalogen-methyl compounds RHONE-POULENC SPECIALITES CHIMIQUES (FR) 1983-11-02 — — EP disclosed
EP-0084742-A1 Process for the acylation of halogen or trihalogen methyl benzenes RHONE-POULENC SPECIALITES CHIMIQUES (FR) 1983-08-03 — — EP disclosed
EP-0084128-A1 Process for the preparation of alkylbenzenes substituted by radicals containing fluorine BAYER AG (DE) 1983-07-27 — — EP disclosed
US-4059610-A Process for preparing isocyanic acid derivatives KAO SOAP CO., LTD. (JA) 1977-11-22 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12338241-B2 Bicyclic sulfones and sulfoxides and methods of use thereof RB1, CCNE2, RPS3A ALDH1A1 1912/4885TSHR 2564/4885PTPN1 1262/4885
US-20260078116-A1 SMALL MOLECULE PROTEIN SYNTHESIS MODULATORS MYC, KRAS, MCL1 ALDH1A1 3887/4885TSHR 3024/4885PTPN1 1161/4885
US-20260109696-A1 SMALL MOLECULE PROTEIN SYNTHESIS MODULATORS KRAS, MYC, NRAS ALDH1A1 3241/4885TSHR 2124/4885PTPN1 1603/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.