Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.44 |
| ▸ | RELA | Q04206 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1272033 | 0.80 | ALDH1A1 (0.44) | POLBALDH1A1 | |
| SCHEMBL19391886 | 0.75 | ALDH1A1 (0.49) | MAPTNPC1ALDH1A1MEN1KMT2A | |
| SCHEMBL25010419 | 0.75 | LMNA (0.55) | LMNAL3MBTL1HDAC3HDAC1HDAC2 | |
| SCHEMBL26773744 | 0.74 | L3MBTL1 (0.53) | LMNAL3MBTL1HDAC3HDAC1HDAC2 | |
| Hydrochloric Acid SCHEMBL28798531 | 0.74 | LMNA (0.54) | LMNAL3MBTL1HDAC3HDAC1HDAC2 | |
| SCHEMBL8813900 | 0.72 | LMNA (0.55) | LMNAL3MBTL1HDAC3HDAC1HDAC2 | |
| SCHEMBL2121276 | 0.72 | LMNA (0.55) | LMNAL3MBTL1HDAC3HDAC1HDAC2 | |
| SCHEMBL28831199 | 0.71 | L3MBTL1 (0.49) | LMNAL3MBTL1HDAC3HDAC1HDAC2 | |
| SCHEMBL12900930 | 0.70 | ALDH1A1 (0.41) | POLBALDH1A1 | |
| SCHEMBL552357 | 0.70 | HDAC1 (0.66) | LMNAL3MBTL1HDAC3HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140142319-A1 | ORGANOACTINIDE-, ORGANOLANTHANIDE-, AND ORGANOGROUP-4-MEDIATED HYDROTHIOLATION OF TERMINAL ALKYNES WITH ALIPHATIC, AROMATIC AND BENZYLIC THIOLS | NORTHWESTERN UNIVERSITY (US) | 2014-05-22 | — | — | US | claimed |
| US-20110040098-A1 | Organoactinide-, Organolanthanide-, and OrganoGroup-4-Mediated Hydrothiolation of Terminal Alkynes with Aliphatic, Aromatic and Benzylic Thiols | NATIONAL SCIENCE FOUNDATION | 2011-02-17 | — | — | US | claimed |
| US-20140142319-A1 | ORGANOACTINIDE-, ORGANOLANTHANIDE-, AND ORGANOGROUP-4-MEDIATED HYDROTHIOLATION OF TERMINAL ALKYNES WITH ALIPHATIC, AROMATIC AND BENZYLIC THIOLS | NORTHWESTERN UNIVERSITY (US) | 2014-05-22 | — | — | US | disclosed |
| US-20140142319-A1 | ORGANOACTINIDE-, ORGANOLANTHANIDE-, AND ORGANOGROUP-4-MEDIATED HYDROTHIOLATION OF TERMINAL ALKYNES WITH ALIPHATIC, AROMATIC AND BENZYLIC THIOLS | NORTHWESTERN UNIVERSITY (US) | 2014-05-22 | — | — | US | disclosed |
| US-20140142319-A1 | ORGANOACTINIDE-, ORGANOLANTHANIDE-, AND ORGANOGROUP-4-MEDIATED HYDROTHIOLATION OF TERMINAL ALKYNES WITH ALIPHATIC, AROMATIC AND BENZYLIC THIOLS | NORTHWESTERN UNIVERSITY (US) | 2014-05-22 | — | — | US | disclosed |
| US-8609902-B2 | Organoactinide-, organolanthanide-, and organogroup-4-mediated hydrothiolation of terminal alkynes with aliphatic, aromatic and benzylic thiols | NORTHWESTERN UNIVERSITY (US) | 2013-12-17 | — | — | US | disclosed |
| US-20110040098-A1 | Organoactinide-, Organolanthanide-, and OrganoGroup-4-Mediated Hydrothiolation of Terminal Alkynes with Aliphatic, Aromatic and Benzylic Thiols | NATIONAL SCIENCE FOUNDATION | 2011-02-17 | — | — | US | disclosed |
| US-20110040098-A1 | Organoactinide-, Organolanthanide-, and OrganoGroup-4-Mediated Hydrothiolation of Terminal Alkynes with Aliphatic, Aromatic and Benzylic Thiols | NATIONAL SCIENCE FOUNDATION | 2011-02-17 | — | — | US | disclosed |
| US-20110040098-A1 | Organoactinide-, Organolanthanide-, and OrganoGroup-4-Mediated Hydrothiolation of Terminal Alkynes with Aliphatic, Aromatic and Benzylic Thiols | NATIONAL SCIENCE FOUNDATION | 2011-02-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140142319-A1 | ORGANOACTINIDE-, ORGANOLANTHANIDE-, AND ORGANOGROUP-4-MEDIATED HYDROTHIOLATION OF TERMINAL ALKYNES WITH ALIPHATIC, AROMATIC AND BENZYLIC THIOLS | OR10J3, HCN4, HVCN1 | LMNA 4882/4885L3MBTL1 598/4885HDAC3 3598/4885 |
| US-20110040098-A1 | Organoactinide-, Organolanthanide-, and OrganoGroup-4-Mediated Hydrothiolation of Terminal Alkynes with Aliphatic, Aromatic and Benzylic Thiols | OR10J3, HCN4, HVCN1 | LMNA 4882/4885L3MBTL1 598/4885HDAC3 3598/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.