Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.73 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.73 |
| ▸ | OPRD1 | P41143 | 6/20 | 0.73 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.73 |
| ▸ | MRGPRX2 | Q96LB1 | 2/20 | 0.73 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.54 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.54 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12324824 | 1.00 | SIGMAR1 (0.73) | SIGMAR1OPRM1OPRD1OPRK1MRGPRX2 | |
| SCHEMBL12267534 | 1.00 | SIGMAR1 (0.73) | SIGMAR1OPRM1OPRD1OPRK1MRGPRX2 | |
| SCHEMBL18623622 | 0.87 | SIGMAR1 (0.56) | SIGMAR1OPRM1OPRD1OPRK1MRGPRX2 | |
| SCHEMBL18623620 | 0.87 | SIGMAR1 (0.56) | SIGMAR1OPRM1OPRD1OPRK1MRGPRX2 | |
| SCHEMBL15706497 | 0.86 | SIGMAR1 (0.58) | SIGMAR1OPRM1OPRD1OPRK1MRGPRX2 | |
| Metazocine SCHEMBL13353229 | 0.84 | OPRM1 (1.00) | SIGMAR1OPRM1OPRD1OPRK1MRGPRX2 | |
| Metazocine SCHEMBL26347 | 0.84 | OPRM1 (1.00) | SIGMAR1OPRM1OPRD1OPRK1MRGPRX2 | |
| Metazocine SCHEMBL12049577 | 0.84 | OPRM1 (1.00) | SIGMAR1OPRM1OPRD1OPRK1MRGPRX2 | |
| Metazocine SCHEMBL21994208 | 0.84 | OPRM1 (1.00) | SIGMAR1OPRM1OPRD1OPRK1MRGPRX2 | |
| Metazocine SCHEMBL29387774 | 0.84 | OPRM1 (1.00) | SIGMAR1OPRM1OPRD1OPRK1MRGPRX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7923454-B2 | morphinan's such as 3-methoxy-17-allylmorphinan hydrobromide used for preventing or treating viral infections, septic shock, organ damage, neurological and cardiovascular disorders, neurodegenerative diseases and cancers | JENKEN BIOSCIENCES, INC. (US) | 2011-04-12 | — | — | US | disclosed |
| US-7501433-B2 | Opioid and opioid-like compounds and uses thereof | JENKEN BIOSCIENCES, INC. (US) | 2009-03-10 | — | — | US | disclosed |