Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT5 | Q9NXA8 | 3/20 | 0.39 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.38 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 7/20 | 0.35 |
| ▸ | CA2 | P00918 | 7/20 | 0.35 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.34 |
| ▸ | TGM2 | P21980 | 2/20 | 0.33 |
| ▸ | ALB | P02768 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13401558 | 0.86 | SIRT1 (0.33) | SIRT5SIRT1CA1CA2 | |
| SCHEMBL13499241 | 0.76 | SIRT5 (0.43) | SIRT5SIRT6SIRT1CA1CA2 | |
| SCHEMBL12910864 | 0.74 | SIRT5 (0.42) | SIRT5SIRT6SIRT1CA1CA2 | |
| SCHEMBL13025173 | 0.74 | SIRT5 (0.41) | SIRT5SIRT6SIRT1CA1CA2 | |
| SCHEMBL4761500 | 0.73 | SIRT6 (0.48) | SIRT5SIRT6SIRT1CA1CA2 | |
| SCHEMBL12721098 | 0.68 | SIRT6 (0.46) | SIRT5SIRT6SIRT1CA1CA2 | |
| SCHEMBL16181039 | 0.67 | TGM2 (0.48) | SIRT5SIRT6SIRT1FOLH1TGM2 | |
| SCHEMBL13901992 | 0.67 | SIRT6 (0.46) | SIRT5SIRT6SIRT1CA1CA2 | |
| SCHEMBL25550095 | 0.67 | FOLH1 (0.64) | SIRT5SIRT6SIRT1FOLH1ALB | |
| SCHEMBL14942518 | 0.67 | FOLH1 (0.64) | SIRT5SIRT6SIRT1FOLH1ALB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7927596-B2 | Methods of antagonizing binding of CD40 to CD40L with CD40L-specific monovalent polypeptides | DOMANTIS LIMITED (GB) | 2011-04-19 | — | — | US | disclosed |