Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.48 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.48 |
| ▸ | SIRT5 | Q9NXA8 | 3/20 | 0.44 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 7/20 | 0.40 |
| ▸ | CA2 | P00918 | 7/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALB | P02768 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13025173 | 0.87 | SIRT5 (0.41) | SIRT6SIRT1SIRT5FOLH1CA1 | |
| SCHEMBL12721098 | 0.83 | SIRT6 (0.46) | SIRT6SIRT1SIRT5FOLH1CA1 | |
| SCHEMBL12910864 | 0.83 | SIRT5 (0.42) | SIRT6SIRT1SIRT5FOLH1CA1 | |
| SCHEMBL13499241 | 0.83 | SIRT5 (0.43) | SIRT6SIRT1SIRT5FOLH1CA1 | |
| SCHEMBL14016183 | 0.82 | AKT1 (0.40) | SIRT6SIRT1CA1CA2 | |
| SCHEMBL10147950 | 0.82 | KDM4E (0.38) | FOLH1KDM4EMAPK1HIF1A | |
| SCHEMBL19546723 | 0.75 | SIRT6 (0.69) | SIRT6SIRT1SIRT5FOLH1CA1 | |
| SCHEMBL21303704 | 0.74 | SIRT1 (0.56) | SIRT6SIRT1SIRT5FOLH1CA1 | |
| SCHEMBL4567600 | 0.74 | SIRT1 (0.56) | SIRT6SIRT1SIRT5FOLH1CA1 | |
| SCHEMBL19681219 | 0.74 | SIRT6 (0.72) | SIRT6SIRT1SIRT5FOLH1CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120123065-A1 | Hydrolytically Stable Maleimide-Terminated Polymers | NEKTAR THERAPEUTICS (US) | 2012-05-17 | — | — | US | disclosed |