Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | RARB | P10826 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | RBP4 | P02753 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | HPN | P05981 | 1/20 | 0.41 |
| ▸ | RPA1 | P27694 | 1/20 | 0.41 |
| ▸ | XBP1 | P17861 | 1/20 | 0.41 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31524118 | 0.80 | EPHX2 (0.48) | ALDH1A1RARBMAPTTDP1 | |
| SCHEMBL31699229 | 0.79 | L3MBTL1 (0.51) | HDAC1L3MBTL1NAMPTMAPTTDP1 | |
| SCHEMBL12932012 | 0.78 | RARB (0.44) | ALDH1A1RARBPLA2G2ARBP4 | |
| SCHEMBL3180689 | 0.77 | L3MBTL1 (0.61) | HDAC1HDAC6L3MBTL1NAMPTMAPT | |
| SCHEMBL28575351 | 0.77 | CACNA1H (0.46) | L3MBTL1ALDH1A1TDP1CYP1A2NPSR1 | |
| SCHEMBL15896355 | 0.76 | ALDH1A1 (0.56) | ALDH1A1RARBPLA2G2A | |
| SCHEMBL7290389 | 0.76 | NOTUM (0.54) | L3MBTL1CYP1A2 | |
| SCHEMBL24088159 | 0.76 | L3MBTL1 (0.50) | HDAC1HDAC6L3MBTL1NAMPTMAPT | |
| SCHEMBL31323275 | 0.75 | JAK2 (0.50) | HDAC1HDAC6ALDH1A1RARBKLKB1 | |
| SCHEMBL21702519 | 0.75 | PLK1 (0.50) | HDAC1HDAC6L3MBTL1NAMPTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3009426-B1 | 4-ALKYNYL IMIDAZOLE DERIVATIVE AND MEDICINE COMPRISING SAME AS ACTIVE INGREDIENT | KAKEN PHARMA CO LTD (JP) | 2018-05-02 | — | — | EP | disclosed |
| EP-2751141-B1 | STABLE PEPTIDE-BASED PACE4 INHIBITORS | SOCPRA SCIENCES SANTE ET HUMAINES S E C (CA) | 2018-03-21 | — | — | EP | disclosed |
| US-9855257-B2 | 4-alkynyl imidazole derivative and medicine comprising same as active ingredient | KAKEN PHARMACEUTICAL CO., LTD. (JP) | 2018-01-02 | — | — | US | disclosed |
| US-9809621-B2 | Stable peptide-based PACE4 inhibitors | SOCPRA SCIENCES SANTÉ ET HUMAINES S.E.C. (CA) | 2017-11-07 | — | — | US | disclosed |
| US-9809621-B2 | Stable peptide-based PACE4 inhibitors | SOCPRA SCIENCES SANTÉ ET HUMAINES S.E.C. (CA) | 2017-11-07 | — | — | US | disclosed |
| US-20170128431-A1 | 4-ALKYNYL IMIDAZOLE DERIVATIVE AND MEDICINE COMPRISING SAME AS ACTIVE INGREDIENT | KAKEN PHARMACEUTICAL CO., LTD. (JP) | 2017-05-11 | — | — | US | disclosed |
| US-20170128431-A1 | 4-ALKYNYL IMIDAZOLE DERIVATIVE AND MEDICINE COMPRISING SAME AS ACTIVE INGREDIENT | KAKEN PHARMACEUTICAL CO., LTD. (JP) | 2017-05-11 | — | — | US | disclosed |
| US-9593081-B2 | 4-alkynyl imidazole derivative and medicine comprising same as active ingredient | KAKEN PHARMACEUTICAL CO., LTD. (JP) | 2017-03-14 | — | — | US | disclosed |
| US-9593081-B2 | 4-alkynyl imidazole derivative and medicine comprising same as active ingredient | KAKEN PHARMACEUTICAL CO., LTD. (JP) | 2017-03-14 | — | — | US | disclosed |
| US-20160130232-A1 | 4-ALKYNYL IMIDAZOLE DERIVATIVE AND MEDICINE COMPRISING SAME AS ACTIVE INGREDIENT | KAKEN PHARMACEUTICAL CO., LTD. (JP) | 2016-05-12 | — | — | US | disclosed |
| EP-3009426-A1 | 4-ALKYNYL IMIDAZOLE DERIVATIVE AND MEDICINE COMPRISING SAME AS ACTIVE INGREDIENT | Kaken Pharmaceutical Co., Ltd. (JP) | 2016-04-20 | — | — | EP | disclosed |
| US-20150141324-A1 | STABLE PEPTIDE-BASED FURIN INHIBITORS | SOCPRA Sciences Sante et Humaines S.E.C. (CA) | 2015-05-21 | — | — | US | disclosed |
| US-20150141324-A1 | STABLE PEPTIDE-BASED FURIN INHIBITORS | SOCPRA Sciences Sante et Humaines S.E.C. (CA) | 2015-05-21 | — | — | US | disclosed |
| US-20140206622-A1 | STABLE PEPTIDE-BASED PACE4 INHIBITORS | SOCPRA Sciences Sante et Humaines S.E.C. (CA) | 2014-07-24 | — | — | US | disclosed |
| US-20140206622-A1 | STABLE PEPTIDE-BASED PACE4 INHIBITORS | SOCPRA Sciences Sante et Humaines S.E.C. (CA) | 2014-07-24 | — | — | US | disclosed |
| WO-2013029180-A1 | STABLE PEPTIDE-BASED PACE4 INHIBITORS | SOCPRA SCIENCES SANTÉ ET HUMAINES S.E.C. (CA) | 2013-03-07 | — | — | WO | disclosed |
| WO-2013029182-A1 | STABLE PEPTIDE-BASED FURIN INHIBITORS | SOCPRA SCIENCES SANTÉ ET HUMAINES S.E.C. (CA) | 2013-03-07 | — | — | WO | disclosed |
| EP-2460787-A1 | Amide compounds and their use as PGE2 antagonists. | Astellas Pharma Inc. (JP) | 2012-06-06 | — | — | EP | disclosed |
| US-20110028463-A1 | AMIDE COMPOUNDS | ASTELLAS PHARMA INC. (JP) | 2011-02-03 | — | — | US | disclosed |
| EP-2172447-A1 | AMIDE COMPOUND | Astellas Pharma Inc. (JP) | 2010-04-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150141324-A1 | STABLE PEPTIDE-BASED FURIN INHIBITORS | FURIN, PREP, VIP | HDAC1 1185/4885HDAC6 1423/4885L3MBTL1 926/4885 |
| US-20160130232-A1 | 4-ALKYNYL IMIDAZOLE DERIVATIVE AND MEDICINE COMPRISING SAME AS ACTIVE INGREDIENT | PTGER4, IL4, PTGER1 | HDAC1 819/4885HDAC6 1806/4885L3MBTL1 4322/4885 |
| US-20140206622-A1 | STABLE PEPTIDE-BASED PACE4 INHIBITORS | FURIN, DNPEP, PRAP1 | HDAC1 1946/4885HDAC6 1209/4885L3MBTL1 1944/4885 |
| US-20170128431-A1 | 4-ALKYNYL IMIDAZOLE DERIVATIVE AND MEDICINE COMPRISING SAME AS ACTIVE INGREDIENT | PTGER4, IL4, PTGER1 | HDAC1 914/4885HDAC6 2103/4885L3MBTL1 4241/4885 |
| US-20110028463-A1 | AMIDE COMPOUNDS | PTGER4, PTGER1, PTGER2 | HDAC1 749/4885HDAC6 2037/4885L3MBTL1 3763/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.