Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HTR1D | P28221 | 2/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.33 |
| ▸ | HTR1B | P28222 | 1/20 | 0.32 |
| ▸ | PDE2A | O00408 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | ACHE | P22303 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12724897 | 0.89 | GABRB2 (0.37) | POLBHTR1DGABRA1GABRB2PDE2A | |
| SCHEMBL12401849 | 0.73 | POLB (0.46) | POLBHTR1DGABRA1GABRB2HTR1B | |
| SCHEMBL24633968 | 0.72 | POLB (0.35) | POLB | |
| SCHEMBL1755242 | 0.72 | POLB (0.44) | POLBHTR1DGABRA1GABRB2HTR1B | |
| SCHEMBL13945812 | 0.71 | POLB (0.44) | POLBHTR1DGABRA1GABRB2HTR1B | |
| SCHEMBL12724995 | 0.71 | GABRA1 (0.37) | POLBHTR1DGABRA1GABRB2ACHE | |
| SCHEMBL13249063 | 0.70 | GABRB2 (0.40) | POLBHTR1DGABRA1GABRB2PDE2A | |
| SCHEMBL2474087 | 0.70 | GABRA1 (0.46) | POLBHTR1DGABRA1GABRB2HTR1B | |
| SCHEMBL8826788 | 0.70 | POLB (0.67) | POLBHTR1DGABRA1GABRB2HTR1B | |
| SCHEMBL12724908 | 0.69 | PDE2A (0.49) | PDE2ACYP2C19ALDH1A1ACHETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932284-B2 | Indole sulfonamide modulators of progesterone receptors | ELI LILLY AND COMPANY (US) | 2011-04-26 | — | — | US | disclosed |
| US-20090069400-A1 | Indole Sulfonamide Modulators of Progesterone Receptors | ELI LILLY AND COMPANY | 2009-03-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090069400-A1 | Indole Sulfonamide Modulators of Progesterone Receptors | PGR, NPSR1, PRLHR | POLB 4449/4885HTR1D 97/4885GABRA1 444/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.