Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.46 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.46 |
| ▸ | ACLY | P53396 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.41 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | TTR | P02766 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6321695 | 0.88 | GABRA1 (0.52) | GABRA1GABRB2ACLYCYP2C19CYP2C9 | |
| SCHEMBL297381 | 0.86 | HSD17B10 (0.46) | CYP2C19CYP2C9CYP1A2SMN1; SMN2ESR1 | |
| SCHEMBL31287202 | 0.86 | HSD17B10 (0.46) | CYP2C19CYP2C9CYP1A2SMN1; SMN2ESR1 | |
| SCHEMBL29065613 | 0.86 | GABRA1 (0.50) | GABRA1GABRB2ACLYCYP2C19CYP2C9 | |
| SCHEMBL201609 | 0.83 | GABRA1 (0.57) | GABRA1GABRB2CYP2C19CYP2C9CYP1A2 | |
| SCHEMBL23542361 | 0.82 | ALDH1A1 (0.46) | GABRA1GABRB2ACLYCYP2C19CYP2C9 | |
| SCHEMBL28119481 | 0.80 | GABRA1 (0.55) | GABRA1GABRB2CYP2C19CYP2C9CYP1A2 | |
| SCHEMBL20371164 | 0.80 | CA2 (0.48) | GABRA1GABRB2ACLYCYP2C19CYP2C9 | |
| SCHEMBL12635966 | 0.80 | PDE2A (0.43) | GABRB2POLBESR1ESR2ALDH1A1 | |
| SCHEMBL814586 | 0.78 | TSHR (0.54) | GABRA1GABRB2ACLYCYP2C19CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8507717-B2 | Production of substituted phenylene aromatic diesters | DOW GLOBAL TECHNOLOGIES LLC (US) | 2013-08-13 | — | — | US | claimed |
| US-20100174105-A1 | Production of Substituted Phenylene Aromatic Diesters | W.R. GRACE & CO.-CONN. | 2010-07-08 | — | — | US | claimed |
| US-8507717-B2 | Production of substituted phenylene aromatic diesters | DOW GLOBAL TECHNOLOGIES LLC (US) | 2013-08-13 | — | — | US | disclosed |
| EP-2373604-A2 | PRODUCTION OF SUBSTITUTED PHENYLENE AROMATIC DIESTERS | Dow Global Technologies LLC (US) | 2011-10-12 | — | — | EP | disclosed |
| WO-2010078512-A2 | PRODUCTION OF SUBSTITUTED PHENYLENE AROMATIC DIESTERS | DOW GLOBAL TECHNOLOGIES INC. (US) | 2010-07-08 | — | — | WO | disclosed |
| US-20100174105-A1 | Production of Substituted Phenylene Aromatic Diesters | W.R. GRACE & CO.-CONN. | 2010-07-08 | — | — | US | disclosed |
| US-7569725-B2 | 2-[(3-chloro-4-hydroxybenzoyl)amino]-N-[2-(2-methoxyphenyl)ethyl]-5-phenoxybenzamide; therapeutic use as anti-cancer agents, as well as other therapeutic agents, for example, as anti-fertility agents | BRITSOL-MYERS SQUIBB COMPANY (US) | 2009-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100174105-A1 | Production of Substituted Phenylene Aromatic Diesters | DDT, COMT, DDC | GABRA1 2114/4885GABRB2 1893/4885ACLY 4241/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.