Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALCRL | Q16602 | 7/20 | 0.34 |
| ▸ | RAMP1 | O60894 | 2/20 | 0.34 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.34 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.34 |
| ▸ | RAMP3 | O60896 | 1/20 | 0.33 |
| ▸ | CALCR | P30988 | 1/20 | 0.33 |
| ▸ | PER2 | O15055 | 2/20 | 0.31 |
| ▸ | CRY2 | Q49AN0 | 2/20 | 0.31 |
| ▸ | APP | P05067 | 1/20 | 0.30 |
| ▸ | BACE1 | P56817 | 1/20 | 0.30 |
| ▸ | METAP2 | P50579 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Potassium Ion SCHEMBL5670572 | 1.00 | CALCRL (0.34) | CALCRLRAMP1HCAR3HCAR2RAMP3 | |
| SCHEMBL3592769 | 0.87 | HCAR3 (0.38) | CALCRLRAMP1HCAR3HCAR2RAMP3 | |
| SCHEMBL12901354 | 0.87 | HCAR3 (0.38) | CALCRLRAMP1HCAR3HCAR2RAMP3 | |
| SCHEMBL12901358 | 0.84 | CALCRL (0.35) | CALCRLRAMP1HCAR3HCAR2RAMP3 | |
| SCHEMBL12936529 | 0.84 | CALCRL (0.35) | CALCRLRAMP1HCAR3HCAR2RAMP3 | |
| SCHEMBL1273412 | 0.71 | HCAR2 (0.38) | CALCRLHCAR3HCAR2PER2CRY2 | |
| Lithium Ion SCHEMBL977109 | 0.70 | CALCRL (0.38) | CALCRLRAMP1RAMP3CALCR | |
| SCHEMBL12921066 | 0.69 | CALCRL (0.34) | CALCRLRAMP1HCAR3HCAR2RAMP3 | |
| SCHEMBL1274621 | 0.68 | CALCRL (0.58) | CALCRLRAMP1 | |
| SCHEMBL12921051 | 0.64 | CALCRL (0.53) | CALCRLRAMP1RAMP3CALCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7893079-B2 | Substituted monocyclic CGRP receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2011-02-22 | — | — | US | disclosed |
| US-20070265225-A1 | Substituted monocyclic CGRP receptor antagonists | MERCK SHARP & DOHME LLC | 2007-11-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070265225-A1 | Substituted monocyclic CGRP receptor antagonists | QRFPR, CALCRL, EDNRB | CALCRL 2/4885RAMP1 70/4885HCAR3 111/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.