Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1274295 | 0.87 | HSD17B10 (0.47) | KMT2AHSD17B10MAPTL3MBTL1MEN1 | |
| SCHEMBL7453183 | 0.83 | F7 (0.51) | — | |
| SCHEMBL7019887 | 0.83 | KMT2A (0.57) | KMT2AHSD17B10MAPTL3MBTL1MEN1 | |
| SCHEMBL5791501 | 0.75 | POLB (0.69) | KMT2AHSD17B10MAPTL3MBTL1MEN1 | |
| SCHEMBL2454105 | 0.75 | POLB (0.69) | KMT2AHSD17B10MAPTL3MBTL1MEN1 | |
| SCHEMBL6989591 | 0.72 | ALDH1A1 (0.34) | KMT2AHSD17B10MAPTMEN1KDM4E | |
| SCHEMBL3594973 | 0.70 | KDM4E (0.49) | HSD17B10KDM4E | |
| SCHEMBL1746215 | 0.69 | MAPT (0.59) | KMT2AHSD17B10MAPTL3MBTL1MEN1 | |
| SCHEMBL9194175 | 0.67 | KMT2A (0.75) | KMT2AHSD17B10MAPTL3MBTL1MEN1 | |
| SCHEMBL9554515 | 0.67 | MAPT (1.00) | KMT2AHSD17B10MAPTL3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7893079-B2 | Substituted monocyclic CGRP receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2011-02-22 | — | — | US | disclosed |