Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 2/20 | 0.36 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.36 |
| ▸ | PNMT | P11086 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12302191 | 0.77 | NOS3 (0.40) | DGAT1SOAT1PNMTNPC1 | |
| SCHEMBL16407785 | 0.77 | MAPT (0.39) | DGAT1SOAT1PNMTNPC1 | |
| SCHEMBL12302201 | 0.77 | PNMT (0.55) | DGAT1SOAT1PNMT | |
| SCHEMBL21130940 | 0.77 | PGR (0.46) | — | |
| SCHEMBL12759775 | 0.72 | DGAT1 (0.36) | DGAT1SOAT1PNMTSLC6A2SLC6A4 | |
| SCHEMBL19485834 | 0.71 | ESR1 (0.30) | — | |
| SCHEMBL10011185 | 0.67 | LMNA (0.53) | NPC1 | |
| SCHEMBL9153089 | 0.66 | CA1 (0.36) | — | |
| SCHEMBL18768868 | 0.66 | LMNA (0.36) | — | |
| SCHEMBL12302193 | 0.66 | DGAT1 (0.47) | DGAT1SOAT1PNMTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7915252-B2 | Sulfonyl compounds as inhibitors of 11-beta-hydroxysteroid dehydrogenase-1 | MERCK SHARP & DOHME (US) | 2011-03-29 | — | — | US | disclosed |