Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 4/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CDC7 | O00311 | 1/20 | 0.30 |
| ▸ | IKBKB | O14920 | 1/20 | 0.30 |
| ▸ | AURKA | O14965 | 1/20 | 0.30 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.30 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.30 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.30 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.30 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.30 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.30 |
| ▸ | CDK1 | P06493 | 1/20 | 0.30 |
| ▸ | FES | P07332 | 1/20 | 0.30 |
| ▸ | RET | P07949 | 1/20 | 0.30 |
| ▸ | IGF1R | P08069 | 1/20 | 0.30 |
| ▸ | ROS1 | P08922 | 1/20 | 0.30 |
| ▸ | PIM1 | P11309 | 1/20 | 0.30 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.30 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3816282 | 0.68 | PDPK1 (0.43) | PDPK1PARP1ALDH1A1CDC7IKBKB | |
| Hypoxanthine SCHEMBL17276814 | 0.64 | ALDH1A1 (0.37) | PDPK1PARP1ALDH1A1CDC7IKBKB | |
| SCHEMBL8664276 | 0.64 | PNP (0.32) | — | |
| SCHEMBL726936 | 0.61 | CNOT7 (0.41) | PDPK1PARP1ALDH1A1 | |
| SCHEMBL7020146 | 0.60 | PDPK1 (0.32) | PDPK1PARP1ALDH1A1 | |
| SCHEMBL22283252 | 0.60 | PDE3B (0.46) | PDPK1PARP1ALDH1A1PIM1PIM3 | |
| SCHEMBL2300776 | 0.59 | ALDH1A1 (0.34) | PDPK1PARP1ALDH1A1CDC7IKBKB | |
| SCHEMBL13627444 | 0.59 | PARP1 (0.36) | PARP1PIM1PIM3 | |
| SCHEMBL12410480 | 0.59 | ADORA1 (0.38) | PARP1ALDH1A1PIM1PIM3 | |
| SCHEMBL725336 | 0.58 | KDM4E (0.33) | PDPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8679472-B1 | Crystal of human interferon alpha 2B in complex with zinc | Merck, Sharp & Dohme Corp. (US) | 2014-03-25 | — | — | US | disclosed |
| US-20110033422-A1 | TREATMENTS FOR FLAVIVIRIDAE VIRUS INFECTION | SCHERING CORPORATION | 2011-02-10 | — | — | US | disclosed |
| US-7816339-B2 | Treatments for Flaviviridae virus infection | SCHERING CORPORATION (US) | 2010-10-19 | — | — | US | disclosed |
| US-7592315-B2 | Peptide viral entry inhibitors | SCHERING CORPORATION (US) | 2009-09-22 | — | — | US | disclosed |
| EP-1824482-A4 | 3, 5-DISUBSTITUTED AND 3,5,7-TRISUBSTITUTED-3H-OXAZOLO AND 3H-THIAZOLO [4,5-d]PYRIMIDIN-2-ONE COMPOUNDS AND PRODRUGS THEREOF | ANADYS PHARMACEUTICALS INC (US) | 2009-08-26 | — | — | EP | disclosed |
| US-20090209483-A1 | TREATMENTS FOR FLAVIVIRIDAE VIRUS INFECTION | SCHERING CORPORATION | 2009-08-20 | — | — | US | disclosed |
| US-7524831-B2 | Treatments for Flaviviridae virus infection | SCHERING CORPORATION (US) | 2009-04-28 | — | — | US | disclosed |
| EP-1899368-A2 | INTERFERON-IGG FUSION | SCHERING CORPORATION (US) | 2008-03-19 | — | — | EP | disclosed |
| EP-1824482-A1 | 3, 5-DISUBSTITUTED AND 3,5,7-TRISUBSTITUTED-3H-OXAZOLO AND 3H-THIAZOLO [4,5-d]PYRIMIDIN-2-ONE COMPOUNDS AND PRODRUGS THEREOF | Anadys Pharmaceuticals, Inc. (US) | 2007-08-29 | — | — | EP | disclosed |
| US-20060269516-A1 | Interferon-IgG fusion | SCHERING CORPORATION | 2006-11-30 | — | — | US | disclosed |
| WO-2006127757-A2 | INTERFERON-IGG FUSION | SCHERING CORPORATION (US) | 2006-11-30 | — | — | WO | disclosed |
| US-20060198824-A1 | Treatments for flaviviridae virus infection | SCHERING CORPORATION | 2006-09-07 | — | — | US | disclosed |
| WO-2006066080-A1 | 3, 5-DISUBSTITUTED AND 3,5,7-TRISUBSTITUTED-3H-OXAZOLO AND 3H-THIAZOLO [4,5-d]PYRIMIDIN-2-ONE COMPOUNDS AND PRODRUGS THEREOF | ANADYS PHARMACEUTICALS, INC. (US) | 2006-06-22 | — | — | WO | disclosed |
| US-20060100148-A1 | Peptide viral entry inhibitors | SCHERING CORPORATION | 2006-05-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060198824-A1 | Treatments for flaviviridae virus infection | HAVCR2, EIF2AK2, HNRNPC | PDPK1 4745/4885PARP1 2235/4885ALDH1A1 464/4885 |
| US-20110033422-A1 | TREATMENTS FOR FLAVIVIRIDAE VIRUS INFECTION | HAVCR2, EIF2AK2, HNRNPC | PDPK1 4745/4885PARP1 2235/4885ALDH1A1 464/4885 |
| US-20090209483-A1 | TREATMENTS FOR FLAVIVIRIDAE VIRUS INFECTION | HAVCR2, EIF2AK2, HNRNPC | PDPK1 4745/4885PARP1 2235/4885ALDH1A1 464/4885 |
| US-20060100148-A1 | Peptide viral entry inhibitors | HAVCR2, VIP, TAP1 | PDPK1 3723/4885PARP1 4579/4885ALDH1A1 4652/4885 |
| US-20060269516-A1 | Interferon-IgG fusion | IFNG, IFNAR1, EIF2AK2 | PDPK1 4713/4885PARP1 3693/4885ALDH1A1 4117/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.