Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.67 |
| ▸ | MEN1 | O00255 | 4/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.67 |
| ▸ | TP53 | P04637 | 3/20 | 0.67 |
| ▸ | HPGD | P15428 | 3/20 | 0.67 |
| ▸ | PKM | P14618 | 3/20 | 0.67 |
| ▸ | LMNA | P02545 | 2/20 | 0.67 |
| ▸ | POLB | P06746 | 2/20 | 0.67 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.65 |
| ▸ | RAB9A | P51151 | 5/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.62 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.62 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.62 |
| ▸ | RELA | Q04206 | 2/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.62 |
| ▸ | CHEK2 | O96017 | 6/20 | 0.61 |
| ▸ | HTT | P42858 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13160197 | 0.88 | HDAC3 (0.65) | NPC1SMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL8603235 | 0.85 | SLC2A1 (0.76) | NPC1SMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL20982659 | 0.84 | NPC1 (0.85) | NPC1SMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL12763751 | 0.82 | MAPT (0.62) | NPC1SMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL12837269 | 0.81 | ALOX5 (0.70) | NPC1SMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL28116665 | 0.81 | ALDH1A1 (0.58) | NPC1SMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL1662754 | 0.80 | MEN1 (0.84) | NPC1SMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL20445326 | 0.80 | SLC2A1 (0.68) | NPC1SMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL6243395 | 0.80 | NPC1 (1.00) | NPC1SMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL2478174 | 0.80 | NPC1 (0.68) | NPC1SMN1; SMN2ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7897622-B2 | 2-amido-5-oxo/thio-benzoic acid derivatives; hepatitis C virus infection; synergistic with another inhibitor of HCV polymerase or immunomodulatory agent such as interferons | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-03-01 | — | — | US | disclosed |
| US-7897622-B2 | 2-amido-5-oxo/thio-benzoic acid derivatives; hepatitis C virus infection; synergistic with another inhibitor of HCV polymerase or immunomodulatory agent such as interferons | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-03-01 | — | — | US | disclosed |
| US-20080045516-A1 | Viral Polymerase Inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-02-21 | — | — | US | disclosed |
| US-20080045516-A1 | Viral Polymerase Inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-02-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080045516-A1 | Viral Polymerase Inhibitors | POLR2A, POLR2H, POLR2E | NPC1 1299/4885SMN1; SMN2 4053/4885ALDH1A1 1625/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.