Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | PRCP | P42785 | 1/20 | 0.37 |
| ▸ | TRHR | P34981 | 2/20 | 0.37 |
| ▸ | ACE | P12821 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.33 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.33 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12820516 | 0.91 | HDAC4 (0.42) | HDAC4HDAC1PRCPACEF2 | |
| SCHEMBL12820514 | 0.89 | HDAC4 (0.41) | HDAC4HDAC1PRCPACEDPP4 | |
| SCHEMBL8281588 | 0.87 | HDAC4 (0.40) | HDAC4HDAC1 | |
| SCHEMBL8293879 | 0.87 | HDAC4 (0.40) | HDAC4HDAC1 | |
| SCHEMBL13766136 | 0.85 | ITGB3 (0.47) | HDAC4HDAC1ACEF2PRSS1 | |
| SCHEMBL1445009 | 0.81 | HDAC4 (0.51) | HDAC4HDAC1ITGB3 | |
| SCHEMBL2812234 | 0.81 | HDAC4 (0.51) | HDAC4HDAC1ITGB3 | |
| SCHEMBL6913804 | 0.80 | TRHR (0.36) | TRHR | |
| SCHEMBL4257792 | 0.80 | HDAC4 (0.49) | HDAC4HDAC1ITGB3 | |
| SCHEMBL4257798 | 0.80 | HDAC4 (0.49) | HDAC4HDAC1ITGB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2305695-A2 | Macrocyclic inhibitors of Hepatitis C virus replication | Intermune, Inc. (US) | 2011-04-06 | — | — | EP | disclosed |
| EP-2305697-A2 | Macrocyclic inhibitors of Hepatitis C virus replication | Intermune, Inc. (US) | 2011-04-06 | — | — | EP | disclosed |
| EP-2305696-A2 | Macrocyclic inhibitors of Hepatitis C virus replication | Intermune, Inc. (US) | 2011-04-06 | — | — | EP | disclosed |