Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKE | Q14164 | 20/20 | 0.51 |
| ▸ | TBK1 | Q9UHD2 | 20/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12522267 | 0.89 | TBK1 (0.66) | IKBKETBK1 | |
| SCHEMBL12801583 | 0.87 | IKBKE (0.56) | IKBKETBK1 | |
| SCHEMBL12801266 | 0.85 | IKBKE (0.54) | IKBKETBK1 | |
| SCHEMBL12801672 | 0.85 | TBK1 (0.57) | IKBKETBK1 | |
| SCHEMBL12801655 | 0.84 | IKBKE (0.60) | IKBKETBK1 | |
| SCHEMBL12801677 | 0.83 | ABL1 (0.53) | IKBKETBK1 | |
| SCHEMBL12801719 | 0.83 | JAK2 (0.55) | IKBKETBK1 | |
| SCHEMBL12800406 | 0.82 | JAK2 (0.56) | IKBKETBK1 | |
| SCHEMBL12801714 | 0.82 | ABL1 (0.55) | IKBKETBK1 | |
| SCHEMBL12801086 | 0.82 | IKBKE (0.56) | IKBKETBK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011046970-A1 | AMINO - PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBKL AND/OR IKK EPSILON | MYREXIS, INC. (US) | 2011-04-21 | — | — | WO | disclosed |