Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 7/20 | 0.33 |
| ▸ | IDH1 | O75874 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.30 |
| ▸ | ABL1 | P00519 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12809589 | 0.94 | HSD11B1 (0.34) | HSD11B1IDH1LMNAHSD17B10ALDH1A1 | |
| SCHEMBL12809752 | 0.89 | CNR2 (0.35) | HSD11B1IDH1LMNAHSD17B10MEN1 | |
| SCHEMBL12809759 | 0.88 | CNR2 (0.37) | HSD11B1IDH1LMNAHSD17B10MEN1 | |
| SCHEMBL12809585 | 0.88 | HTT (0.38) | HSD11B1IDH1LMNAHSD17B10ALDH1A1 | |
| SCHEMBL12809583 | 0.88 | HTT (0.38) | HSD11B1IDH1LMNAHSD17B10ALDH1A1 | |
| SCHEMBL1406991 | 0.86 | LMNA (0.44) | HSD11B1LMNASMN1; SMN2HPGD | |
| SCHEMBL12809588 | 0.82 | HSD11B1 (0.39) | HSD11B1LMNAHSD17B10ALDH1A1KDM4E | |
| SCHEMBL12809751 | 0.82 | HSD11B1 (0.39) | HSD11B1LMNAHSD17B10ALDH1A1KDM4E | |
| SCHEMBL12809749 | 0.82 | LMNA (0.39) | HSD11B1IDH1LMNAHSD17B10ALDH1A1 | |
| SCHEMBL12809778 | 0.80 | HTT (0.38) | HSD11B1LMNAHSD17B10ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2295411-A1 | Pyrazoles as 11-beta-hsd-1 | F. Hoffmann-La Roche AG (CH) | 2011-03-16 | — | — | EP | disclosed |
| WO-2007107470-A2 | PYRAZOLES AS 11-BETA-HSD-1 | F. HOFFMANN-LA ROCHE AG (CH) | 2007-09-27 | — | — | WO | disclosed |