Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 3/20 | 0.41 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.43 |
| ▸ | MAPT | P10636 | 8/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | CASP1 | P29466 | 3/20 | 0.43 |
| ▸ | ATM | Q13315 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL12813168 | 0.98 | HTR3A (0.46) | HTR3AALDH1A1MAPTKDM4EHSD17B10 | |
| SCHEMBL12273001 | 0.98 | HTR3A (0.48) | HTR3AALDH1A1MAPTKDM4EHSD17B10 | |
| Iodide SCHEMBL11279046 | 0.90 | KMT2A (0.48) | HTR3AALDH1A1MAPTKDM4EHSD17B10 | |
| SCHEMBL146313 | 0.88 | KMT2A (0.50) | HTR3AALDH1A1MAPTKDM4EHSD17B10 | |
| SCHEMBL30165715 | 0.88 | KMT2A (0.50) | HTR3AALDH1A1MAPTKDM4EHSD17B10 | |
| Hydrochloric Acid SCHEMBL40555 | 0.86 | MAPT (0.50) | HTR3AALDH1A1MAPTKDM4EHSD17B10 | |
| Iodide SCHEMBL1471059 | 0.82 | MAPT (0.53) | ALDH1A1MAPTKDM4EHSD17B10SMN1; SMN2 | |
| Water SCHEMBL1146714 | 0.80 | MAPT (0.50) | ALDH1A1MAPTKDM4EHSD17B10SMN1; SMN2 | |
| SCHEMBL50667 | 0.79 | MAPT (0.56) | ALDH1A1MAPTKDM4EHSD17B10SMN1; SMN2 | |
| SCHEMBL12620639 | 0.78 | KDM4E (0.43) | ALDH1A1MAPTKDM4EHSD17B10SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8809317-B2 | Antiviral compounds | PROSETTA ANTIVIRAL INC. (US) | 2014-08-19 | — | — | US | disclosed |
| US-20120302556-A1 | Antiviral Compounds | PROSETTA ANTIVIRAL INC. (US) | 2012-11-29 | — | — | US | disclosed |
| WO-2012135402-A1 | ANTIVIRAL COMPOUNDS | PROSTETTA ANTIVIRAL INC. (US) | 2012-10-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120302556-A1 | Antiviral Compounds | HAVCR2, MAVS, EIF2AK2 | ACHE 737/4885CHRM1 4826/4885HTR3A 3128/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.