Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.42 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.37 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.37 |
| ▸ | ADORA3 known ✓ | P0DMS8 | 1/20 | 0.37 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.37 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.37 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.37 |
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.37 |
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.37 |
| ▸ | CACNA1B known ✓ | Q00975 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 7/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | GLA | P06280 | 4/20 | 0.42 |
| ▸ | NQO2 | P16083 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL1146708 | 0.97 | MAPT (0.48) | MAPTALDH1A1HPGDGLAACHE | |
| Iodide SCHEMBL1471059 | 0.97 | MAPT (0.53) | MAPTALDH1A1HPGDGLAACHE | |
| SCHEMBL50667 | 0.95 | MAPT (0.56) | MAPTALDH1A1HPGDGLAACHE | |
| Hydrochloric Acid SCHEMBL31542018 | 0.92 | MAPT (0.53) | MAPTALDH1A1HPGDGLAACHE | |
| Hydrochloric Acid SCHEMBL740017 | 0.92 | MAPT (0.53) | MAPTALDH1A1HPGDGLAACHE | |
| SCHEMBL3360974 | 0.81 | MAPT (0.42) | MAPTALDH1A1HPGDGLAACHE | |
| SCHEMBL8987972 | 0.80 | MAPT (0.40) | MAPTALDH1A1HPGDGLAACHE | |
| Iodide SCHEMBL2590189 | 0.80 | KDM4E (0.40) | KDM4EKCNH2 | |
| Iodide SCHEMBL12813166 | 0.80 | HTR3A (0.47) | MAPTALDH1A1HPGDGLAACHE | |
| Iodide SCHEMBL12813168 | 0.78 | HTR3A (0.46) | MAPTALDH1A1HPGDGLAACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7344823-B2 | Transient optical state change materials useful in copy-protected compact discs | VERIFICATION TECHNOLOGIES, INC. (US) | 2008-03-18 | — | — | US | claimed |
| EP-4651874-A2 | PHENOTHIAZINYL COMPOUNDS AND USES | Prosetta Biosciences, Inc. (US) | 2025-11-26 | — | — | EP | disclosed |
| US-20250172566-A1 | SACCHARIDE SENSING SYSTEMS | Carbometrics Limited (GB) | 2025-05-29 | — | — | US | disclosed |
| EP-4469803-A1 | SACCHARIDE SENSING SYSTEMS | Carbometrics Limited (GB) | 2024-12-04 | — | — | EP | disclosed |
| US-20240300940-A1 | Phenothiazinyl Compounds and Uses | PROSETTA BIOSCIENCES, INC., | 2024-09-12 | — | — | US | disclosed |
| WO-2024178120-A2 | PHENOTHIAZINYL COMPOUNDS AND USES | PROSETTA BIOSCIENCES, INC. (US) | 2024-08-29 | — | — | WO | disclosed |
| WO-2023144545-A1 | SACCHARIDE SENSING SYSTEMS | Carbometrics Limited (GB) | 2023-08-03 | — | — | WO | disclosed |
| US-9540405-B2 | Diaminophenothiazinium derivatives for labelling biomolecules, method and substrate for labelling oligonucleotides, and oligonucleotides obtained | UNIVERSITE CLAUDE BERNARD LYON I (FR) | 2017-01-10 | — | — | US | disclosed |
| US-20150011712-A1 | DIAMINOPHENOTHIAZINIUM DERIVATIVES FOR LABELLING BIOMOLECULES, METHOD AND SUBSTRATE FOR LABELLING OLIGONUCLEOTIDES, AND OLIGONUCLEOTIDES OBTAINED | UNIVERSITE CLAUDE BERNARD LYON I (FR) | 2015-01-08 | — | — | US | disclosed |
| US-8809317-B2 | Antiviral compounds | PROSETTA ANTIVIRAL INC. (US) | 2014-08-19 | — | — | US | disclosed |
| EP-1687286-A1 | DEVELOPMENTS IN BIOLOGICALLY ACTIVE METHYLENE BLUE DERIVATIVES (2) | Photopharmica Limited (GB) | 2006-08-09 | — | — | EP | disclosed |
| WO-2006032847-A1 | WOUND HEALING | PHOTOPHARMICA LIMITED (GB) | 2006-03-30 | — | — | WO | disclosed |
| EP-1551817-A2 | TRANSIENT OPTICAL STATE CHANGE MATERIALS USEFUL IN COPY-PROTECTED COMPACT DISCS | Verification Technologies, Inc. (US) | 2005-07-13 | — | — | EP | disclosed |
| WO-2005054217-A1 | DEVELOPMENTS IN BIOLOGICALLY ACTIVE METHYLENE BLUE DERIVATIVES (2) | PHOTOPHARMICA LIMITED (GB) | 2005-06-16 | — | — | WO | disclosed |
| EP-1532623-A1 | MATERIALS FOR OPTICAL MEDIUM COPY-PROTECTION TRANSIENTLY REACTING TO A READER BEAM | Verification Technologies, Inc. (US) | 2005-05-25 | — | — | EP | disclosed |
| US-20040147508-A1 | Biologically active methylene blue derivatives | PHOTOPHARMICA LIMITED | 2004-07-29 | — | — | US | disclosed |
| US-20040121262-A1 | Transient optical state change materials useful in copy-protected compact discs | SPENCER TRASK HEALTHCARE VENTURES LLC | 2004-06-24 | — | — | US | disclosed |
| WO-2004029672-A2 | TRANSIENT OPTICAL STATE CHANGE MATERIALS USEFUL IN COPY-PROTECTED COMPACT DISCS | VERIFICATION TECHNOLOGIES, INC. (US) | 2004-04-08 | — | — | WO | disclosed |
| US-20040004922-A1 | Materials for optical medium copy-protection transiently reacting to a reader beam | VERIFICATION TECHNOLOGIES, INC. | 2004-01-08 | — | — | US | disclosed |
| WO-2003107331-A1 | MATERIALS FOR OPTICAL MEDIUM COPY-PROTECTION TRANSIENTLY REACTING TO A READER BEAM | VERIFICATION TECHNOLOGIES, INC. (US) | 2003-12-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150011712-A1 | DIAMINOPHENOTHIAZINIUM DERIVATIVES FOR LABELLING BIOMOLECULES, METHOD AND SUBSTRATE FOR LABELLING OLIGONUCLEOTIDES, AND OLIGONUCLEOTIDES OBTAINED | POLRMT, RNASEH1, PDXK | ACHE 2906/4885CHRM2 1395/4885ADRA2A 2719/4885 |
| US-20250172566-A1 | SACCHARIDE SENSING SYSTEMS | GALE, SLC2A8, SLC2A4 | ACHE 2800/4885CHRM2 4559/4885ADRA2A 4431/4885 |
| US-20040147508-A1 | Biologically active methylene blue derivatives | HCCS, CYBA, HMBS | ACHE 4014/4885CHRM2 1235/4885ADRA2A 2930/4885 |
| US-20040121262-A1 | Transient optical state change materials useful in copy-protected compact discs | RAD51, VCL, TRRAP | ACHE 2336/4885CHRM2 3007/4885ADRA2A 4042/4885 |
| US-20240300940-A1 | Phenothiazinyl Compounds and Uses | PSEN1, ACE, APP | ACHE 5/4885CHRM2 2682/4885ADRA2A 3553/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.