Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 15/20 | 0.44 |
| ▸ | BRD2 | P25440 | 7/20 | 0.43 |
| ▸ | BRD3 | Q15059 | 6/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.37 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12818102 | 0.83 | BRD4 (0.45) | BRD4BRD2BRD3POLB | |
| SCHEMBL12817919 | 0.81 | BRD4 (0.41) | BRD4BRD2BRD3DRD2HTR2A | |
| SCHEMBL12817768 | 0.80 | BRD4 (0.40) | BRD4BRD2BRD3DRD2HTR2A | |
| SCHEMBL12818772 | 0.80 | BRD4 (0.45) | BRD4BRD2BRD3POLBDRD2 | |
| SCHEMBL12817775 | 0.79 | GAA (0.40) | POLBGAAATMSMYD3 | |
| SCHEMBL12818942 | 0.77 | GAA (0.42) | POLBGAAATMDRD2HTR2A | |
| SCHEMBL12818258 | 0.77 | GAA (0.39) | POLBGAAATM | |
| SCHEMBL12817972 | 0.75 | GAA (0.40) | POLBGAAATM | |
| SCHEMBL12817717 | 0.75 | GAA (0.40) | POLBGAAATM | |
| SCHEMBL12818288 | 0.75 | BRD4 (0.42) | BRD4BRD2BRD3DRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012130306-A1 | BICYCLIC 2,3-DIHYRDOBENZAZINE COMPOUNDS FOR USE IN THERAPY | ELARA PHARMACEUTICALS GMBH (DE) | 2012-10-04 | — | — | WO | disclosed |