Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.54 |
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | KCNJ5 | P48544 | 4/20 | 0.52 |
| ▸ | KCNJ3 | P48549 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.50 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.50 |
| ▸ | CLK2 | P49760 | 1/20 | 0.50 |
| ▸ | PRKX | P51817 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24686030 | 0.79 | ROCK2 (0.49) | MEN1KMT2AMAPTPOLBL3MBTL1 | |
| SCHEMBL24687088 | 0.79 | ROCK2 (0.49) | MEN1KMT2AMAPTPOLBL3MBTL1 | |
| SCHEMBL24687090 | 0.76 | ADAMTS4 (0.51) | MEN1KMT2AMAPTPOLBL3MBTL1 | |
| SCHEMBL19576777 | 0.75 | P2RX4 (0.61) | ROCK2P2RX4 | |
| SCHEMBL24686679 | 0.74 | RECQL (0.47) | MEN1KMT2AMAPTPOLBL3MBTL1 | |
| SCHEMBL26186442 | 0.73 | ROCK2 (0.49) | POLBL3MBTL1ALDH1A1ROCK2P2RX4 | |
| SCHEMBL30285583 | 0.73 | ROCK2 (0.49) | POLBL3MBTL1ALDH1A1ROCK2P2RX4 | |
| SCHEMBL24686724 | 0.73 | ADAMTS4 (0.46) | MEN1KMT2AMAPTPOLBL3MBTL1 | |
| SCHEMBL13329827 | 0.73 | P2RX7 (0.52) | — | |
| SCHEMBL837387 | 0.73 | P2RX7 (0.49) | MAPTPOLBALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2295412-A1 | Indazole compounds useful as protein kinase inhibitors | Vertex Pharmaceuticals Incorporated (US) | 2011-03-16 | — | — | EP | disclosed |