Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 6/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.42 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.42 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12831721 | 0.81 | CRHR1 (0.37) | TSHRGABRA1LMNAGABRB2GABRG2 | |
| SCHEMBL13031107 | 0.72 | TSHR (0.57) | TSHRLMNAHPGDATMMEN1 | |
| SCHEMBL16939382 | 0.68 | PDE10A (0.43) | TSHRLMNAATMMEN1KMT2A | |
| SCHEMBL5455913 | 0.68 | PRMT5 (0.60) | TSHRGABRA1LMNAGABRB2GABRG2 | |
| SCHEMBL22063132 | 0.66 | LMNA (0.33) | TSHRGABRA1LMNAGABRB2GABRG2 | |
| SCHEMBL24371884 | 0.66 | CYP1A2 (0.47) | TSHRGABRA1LMNAGABRB2GABRG2 | |
| SCHEMBL18368385 | 0.63 | DPP4 (0.39) | TSHRGABRA1LMNAGABRB2GABRG2 | |
| SCHEMBL18368377 | 0.63 | KEAP1 (0.46) | TSHRGABRA1LMNAGABRB2GABRG2 | |
| SCHEMBL19105564 | 0.62 | GABRA1 (0.45) | TSHRGABRA1LMNAGABRB2GABRG2 | |
| SCHEMBL16640352 | 0.62 | BCHE (0.43) | TSHRGABRA1LMNAGABRB2GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011038293-A1 | CYCLIC PEPTIDE INHIBITORS OF HEPATITIS C VIRUS REPLICATION | INTERMUNE, INC. (US) | 2011-03-31 | — | — | WO | disclosed |