Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | CASP3 | P42574 | 2/20 | 0.47 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.47 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.47 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 7/20 | 0.45 |
| ▸ | MAPT | P10636 | 6/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1507049 | 0.96 | TBXAS1 (0.51) | TBXAS1ALDH1A1L3MBTL1NPC1RAB9A | |
| SCHEMBL12833645 | 0.86 | TBXAS1 (0.54) | TBXAS1ALDH1A1L3MBTL1NPC1RAB9A | |
| SCHEMBL29906409 | 0.83 | TBXAS1 (0.60) | TBXAS1ALDH1A1L3MBTL1NPC1RAB9A | |
| SCHEMBL12761935 | 0.83 | TBXAS1 (0.60) | TBXAS1ALDH1A1L3MBTL1NPC1RAB9A | |
| SCHEMBL7912380 | 0.83 | TBXAS1 (0.69) | TBXAS1ALDH1A1L3MBTL1NPC1RAB9A | |
| SCHEMBL12834660 | 0.82 | DRD4 (0.49) | L3MBTL1LMNAMAPTKMT2ATDP1 | |
| SCHEMBL1507122 | 0.82 | P4HB (0.54) | TBXAS1ALDH1A1LMNAMAPTKMT2A | |
| SCHEMBL12761938 | 0.82 | TBXAS1 (0.59) | TBXAS1ALDH1A1L3MBTL1NPC1RAB9A | |
| SCHEMBL12833639 | 0.82 | TBXAS1 (0.59) | TBXAS1ALDH1A1L3MBTL1NPC1RAB9A | |
| SCHEMBL12833647 | 0.81 | ALDH1A1 (0.62) | TBXAS1ALDH1A1L3MBTL1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257515-B1 | 1,4-NAPHTHOQUINONE DERIVATIVES AND THERAPEUTIC USE THEREOF | CENTRE NAT RECH SCIENT (FR) | 2017-05-17 | — | — | EP | disclosed |
| US-9090549-B2 | 1,4-naphthoquinones derivatives and therapeutic use thereof | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) (FR) | 2015-07-28 | — | — | US | disclosed |
| US-20110059972-A1 | 1,4-NAPHTHOQUINONES DERIVATIVES AND THERAPEUTIC USE THEREOF | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2011-03-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110059972-A1 | 1,4-NAPHTHOQUINONES DERIVATIVES AND THERAPEUTIC USE THEREOF | NQO1, NDUFV2, RECQL | TBXAS1 183/4885ALDH1A1 539/4885L3MBTL1 4372/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.