Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 6/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | NPC1 | O15118 | 5/20 | 0.42 |
| ▸ | RAB9A | P51151 | 5/20 | 0.42 |
| ▸ | GAA | P10253 | 5/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | GLA | P06280 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14091277 | 0.84 | HPGD (0.46) | HPGDSMN1; SMN2KDM4EALDH1A1NPC1 | |
| SCHEMBL6800084 | 0.81 | PARP1 (0.44) | KDM4ERAB9APARP1 | |
| SCHEMBL1895948 | 0.81 | NPC1 (0.55) | HPGDSMN1; SMN2KDM4EALDH1A1NPC1 | |
| SCHEMBL28671805 | 0.71 | NPC1 (0.65) | HPGDSMN1; SMN2KDM4EALDH1A1NPC1 | |
| SCHEMBL14091530 | 0.70 | HPGD (0.43) | HPGDSMN1; SMN2KDM4EALDH1A1NPC1 | |
| SCHEMBL9718869 | 0.70 | ALDH1A1 (0.65) | HPGDSMN1; SMN2KDM4EALDH1A1NPC1 | |
| SCHEMBL6439292 | 0.70 | ALDH1A1 (0.60) | HPGDSMN1; SMN2KDM4EALDH1A1NPC1 | |
| SCHEMBL16940832 | 0.69 | ALDH1A1 (0.65) | HPGDSMN1; SMN2KDM4EALDH1A1NPC1 | |
| SCHEMBL14532237 | 0.69 | ALDH1A1 (0.65) | HPGDSMN1; SMN2KDM4EALDH1A1NPC1 | |
| SCHEMBL2379590 | 0.69 | ALOX15 (0.48) | HPGDSMN1; SMN2KDM4EALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2298770-A1 | Heterocyclic compounds as TrkA modulators | ChemBridge Corporation (US) | 2011-03-23 | — | — | EP | disclosed |