Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.36 |
| ▸ | DRD2 | P14416 | 4/20 | 0.34 |
| ▸ | DRD3 | P35462 | 4/20 | 0.34 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12178857 | 0.82 | CHRNB2 (0.34) | — | |
| SCHEMBL12836282 | 0.80 | SIGMAR1 (0.51) | OPRM1OPRL1DRD2DRD3SIGMAR1 | |
| SCHEMBL12836222 | 0.80 | OPRM1 (0.41) | OPRM1OPRL1SLC18A3SIGMAR1GRIN1 | |
| SCHEMBL12179327 | 0.74 | CHRM2 (0.38) | OPRM1OPRL1SLC18A3SIGMAR1GRIN1 | |
| SCHEMBL10008667 | 0.71 | SLC6A4 (0.41) | OPRM1OPRL1DRD2DRD3HDAC4 | |
| SCHEMBL12178866 | 0.70 | OPRM1 (0.42) | OPRM1OPRL1 | |
| SCHEMBL12178751 | 0.69 | CHRM2 (0.44) | DRD2DRD3DRD4 | |
| SCHEMBL12178832 | 0.68 | HTR1A (0.32) | — | |
| SCHEMBL12179170 | 0.68 | OPRM1 (0.36) | OPRM1OPRL1 | |
| SCHEMBL12836641 | 0.67 | NPY1R (0.43) | OPRM1OPRL1SLC18A3SIGMAR1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011033255-A1 | (4-PHENYL-PIPERIDIN-1-YL)-[5-1H-PYRAZOL-4YL)-THIOPHEN-3-YL]-METHANONE COMPOUNDS AND THEIR USE | THE UNIVERSITY OF EDINBURGH (GB) | 2011-03-24 | — | — | WO | disclosed |