SCHEMBL3446

SCHEMBL3446

C=C1c2c(Cl)ccc(O)c2C(O)=C2C(=O)C3(O)C(=O)C(=C(N)O)C(=O)C(N(C)C)C3C(O)C12

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 14/20 0.62
KDM4E B2RXH2 11/20 0.62
MEN1 O00255 9/20 0.62
KMT2A Q03164 9/20 0.62
USP2 O75604 8/20 0.62
HSD17B10 Q99714 8/20 0.62
RECQL P46063 7/20 0.62
HPGD P15428 7/20 0.62
ALDH1A1 P00352 7/20 0.62
THRB P10828 6/20 0.62
MAPT P10636 6/20 0.62
LMNA P02545 4/20 0.62
L3MBTL1 Q9Y468 3/20 0.62
CASP7 P55210 2/20 0.62
CASP1 P29466 1/20 0.62
SMN1; SMN2 Q16637 1/20 0.62
NR1I2 O75469 3/20 0.55
MC4R P32245 1/20 0.55
SIRT5 Q9NXA8 1/20 0.55
POLB P06746 4/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1650332 1.00 TDP1 (0.62) TDP1KDM4EMEN1KMT2AUSP2
SCHEMBL12841672 1.00 TDP1 (0.62) TDP1KDM4EMEN1KMT2AUSP2
Sulfosalicylic SCHEMBL23359126 0.88 TDP1 (0.81) TDP1KDM4EMEN1KMT2AUSP2
SCHEMBL4015 0.86 TDP1 (0.73) TDP1KDM4EMEN1KMT2AUSP2
SCHEMBL23247761 0.85 TDP1 (0.78) TDP1KDM4EMEN1KMT2AUSP2
SCHEMBL29487299 0.85 TDP1 (0.78) TDP1KDM4EMEN1KMT2AUSP2
Hydrochloric Acid SCHEMBL20398184 0.84 TDP1 (0.71) TDP1KDM4EMEN1KMT2AUSP2
Sulfosalicylic SCHEMBL29674900 0.77 TDP1 (1.00) TDP1KDM4EMEN1KMT2AUSP2
Isoniazid SCHEMBL5791571 0.76 TDP1 (0.61) TDP1KDM4EMEN1KMT2AUSP2
SCHEMBL23005369 0.73 TDP1 (0.73) TDP1KDM4EMEN1KMT2AUSP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 7184 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2026105164-A1 NON-AQUEOUS LIQUID FORMULATIONS OF TETRACYCLINE ANTIBIOTICS ETICO LIFESCIENCES PRIVATE LIMITED (IN) 2026-05-21 WO claimed
US-20260139860-A1 PRODUCTS OF MANUFACTURE FOR THE TREATMENT, PREVENTION AND AMELIORATION OF MICROBIAL INFECTIONS CENTRE FOR DIGESTIVE DISEASES (AU) 2026-05-21 US claimed
EP-4007582-B1 ANTIBIOTICS IN COMBINATION WITH PHOTODYNAMIC THERAPY FOR USE IN A METHOD OF ENHANCING THE ANTIMICROBIAL ACTION OF SYSTEMICALLY ADMINISTERED ANTIBIOTICS KOITE HEALTH OY (FI) 2026-05-20 EP claimed
US-20260108619-A1 CONJUGATION LINKERS, CELL BINDING MOLECULE-DRUG CONJUGATES CONTAINING THE LINKERS, METHODS OF MAKING AND USES SUCH CONJUGATES WITH THE LINKERS HANGZHOU DAC BIOTECH CO., LTD. (CN) 2026-04-23 US claimed
US-20260108455-A1 DEVICE FOR SUSTAINED CONTROLLED RELEASE OF A THERAPEUTICALLY ACTIVE SUBSTANCE AND USES THEREOF HYLOMORPH AG (CH) 2026-04-23 US claimed
EP-4727558-A1 NOVEL METHOD EMPLOYING ANTIBIOTICS WITH ACCRETION TO APATITE COATED IMPLANTS PREVENTING BACTERIAL ATTACHMENT AND INFECTION Moroxite I AB (SE) 2026-04-22 EP claimed
US-12576124-B2 Formulation of a conjugate of a tubulysin analog to a cell-binding molecule HANGZHOU DAC BIOTECH CO., LTD (CN) 2026-03-17 US claimed
EP-4554557-B1 DEVICE FOR SUSTAINED CONTROLLED RELEASE OF A THERAPEUTICALLY ACTIVE SUBSTANCE AND USES THEREOF HYLOMORPH AG (CH) 2026-03-11 EP claimed
EP-4684811-A1 NOVEL TREATMENT REGIMEN AND METHODS IN BONE HEALING Moroxite AB (SE) 2026-01-28 EP claimed
EP-4680248-A1 PRODUCTS OF MANUFACTURE AND THERAPEUTIC COMPOSITIONS FOR TREATING, AMELIORATING OR PREVENTING VIRAL INFECTIONS AND METHODS FOR MAKING AND USING THEM Topelia Aust Limited (ACN 652 771 670) (AU) 2026-01-21 EP claimed
WO-1994002176-A1 PHARMACEUTICAL COMPOSITION FOR TOPICAL USE CONTAINING A CROSSLINKED CATIONIC POLYMER AND AN ALKOXYLATED ETHER THE PROCTER & GAMBLE COMPANY (US) 1994-02-03 WO claimed
US-5260066-A Cryogel bandage containing therapeutic agent SRCHEM INCORPORATED (US) 1993-11-09 US claimed
CN-1072863-A Be used to improve the dermal osmosis system of the reinforcement of medicine localized delivery RICHARDSON VICKS INC (US) 1993-06-09 CN claimed
CN-1072602-A Improve the enhanced dermal osmosis system of the local conveying of medicine RICHARDSON VICKS INC (US) 1993-06-02 CN claimed
WO-1993007902-A1 ENHANCED SKIN PENETRATION SYSTEM FOR IMPROVED TOPICAL DELIVERY OF DRUGS RICHARDSON-VICKS, INC. (US) 1993-04-29 WO claimed
WO-1993007903-A1 ENHANCED SKIN PENETRATION SYSTEM FOR IMPROVED TOPICAL DELIVERY OF DRUGS RICHARDSON-VICKS, INC. (US) 1993-04-29 WO claimed
WO-1993007856-A1 LOW pH AQUEOUS COSMETIC GEL CONTAINING NON-IONIC POLYACRYLAMIDE DERIVATIVES RICHARDSON-VICKS, INC. (US) 1993-04-29 WO claimed
US-5082656-A Antibiotic, polymer, plasticizer, solvent ABBOTT LABORATORIES (US) 1992-01-21 US claimed
EP-0413528-A1 Amphoteric compositions and polymeric forms of alpha hydroxyacids, and their therapeutic use Yu, Ruey J., Dr. (US) 1991-02-20 EP claimed
EP-0273202-A2 Use of hydroxycarboxylic acids to enhance therapeutic effects of topical compositions for fungal infections and pigmented spots. Van Scott, Eugene J., Dr. (US) 1988-07-06 EP claimed